The main purpose of the PICASSO-project is to facilitate future psoriasis-research in dermatology. This register biobank will enable us to perform research in the field of metabolomics, mRNA-expression, cardiovascular impact and the microbiome. The final aims are patient stratification, better insight in disease-evolution and improved understanding of markers that predispose to severe disease.

The PICASSO-project is a prospective register with extensive biobanking in which patients with a recent onset of psoriasis (<3 years) can be enrolled. Participants are followed for a period of 10 years, with scheduled visits every 2.5 years. The same protocol is followed for every visit. The registry captures patient demographics, medical history (personal and family), details of psoriasis treatment (previous and current), physical examination, disease activity scores and PROMs. Some patients (substudy) will undergo ultra-sound to determine carotid intima media thickness. Biobanking in this project encompasses extensive biosampling of multiple tissues. It is not within the scope of this project to administer study medication: patients receive standard of care treatment as prescribed by their physician.

Inclusion Criteria:

• Clinical signs of Psoriasis since >3 years
• adults (70 years old or less) and children (>12 years old)
• willing and able to understand and sign the informed consent (plus legal representative in case of a minor)

Exclusion Criteria:

• unwilling or unable to understand and sign the informed consent
• disease duration longer than 3 years

Psoriasis patients with disease duration less than three years, aged 12-70 years old at time of inclusion

No IPD will be shared. Data on cohort-level will be published.