While delivery of an FMT-treatment to the cecum is visualized in a lower GI-endoscopy, it is uncertain whether delivery by enema distributes the FMT to the proximal segments of the colon. Positioning of the patient during the enema procedure may improve distribution to the proximal colon. Differences in distribution may explain the wide effect range and inferiority when enema is compared to delivery by lower GI endoscopy. Thus, in this study we will compare the distribution of FMT from delivery by lower GI endoscopy versus enema with and without positioning of the patient. We will use contrast fluid as a surrogate liquid for FMT to project the distribution on colon X-ray pictures. To our knowledge this is not done in any previous study.

Inclusion Criteria:

• Scheduled for colonoscopy at the medical department at UNN Harstad
• Able to complete the positioning procedure during the enema

Exclusion Criteria:

• Confirmed malignancy
• Inflammatory bowel disease
• Referral highly suspicious of cancer, inflammatory bowel disease or obstructive GI disease
• Contraindications for rectal catheter insertion (including known damage to pelvic floor, sphincter or the pudendal nerve)
• Use of anticoagulants. Use of acetylsalicylic acid is allowed
• Symptomatic cardiovascular or lung disease
• Kidney failure
• Known allergic reaction to any component in Liquid Polibar Plus
• Pregnant, lactating or planning pregnancy
• Asthma

Study protocol with statistical analysis plan will be uploaded to the ClinicalTrials.gov web site.

Within 2021