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Investigation of the microalgae Phaeodactylum as food with regard to the uptake of omega-3 fatty acids and effects on various blood parameters in relation to age.
Bioavailability and excretion of nutrients and their effects on fatty acid status and inflammatory markers.
Due to a multifaceted redesign of all areas of life, older people face many nutritional challenges, such as cognitive change, sarcopenia and micronutrient deficiency. In addition to age-associated diseases, cognitive decline is usually a precursor to neurodegenerative processes, such as Alzheimer's disease. The full molecular mechanisms are still unknown, but classic aging mechanisms, such as oxidative stress and subclinical inflammation, play a role. Due to the changed life situation, there is a reduced need for energy, while the need for nutrients remains, which greatly increases the risk of malnutrition in old age. This results in an increasing prevalence of sarcopenia. The decrease in muscle mass and strength leads to functional limitations in the elderly and also promotes oxidative stress. This increases the need for antioxidant nutrients such as carotenoids and vitamins. Studies show that age-related chronic subclinical inflammation, such as occurs in the context of an omega-6 fatty acid (-FS) emphasized diet, plays a central role in the pathogenesis of age-associated diseases
Due to this, the microalgae PT could be a goud supplier of nutrients like omega-3 FS, especially eicosapentaenoic acid (EPA), which is otherwise found mainly in fatty fish, and Fucoxanthin, an antioxidant. The investigator study the change of omega-3, -6 and -9 FS in blood plasma, in erythrocytes, as well as the change of fucoxanthin and beta-carotene. The investigator measure blood parameters for safety and control the influence on the intestinal barrier.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | 14 days wahs-out: no fish eating 14 days: no fish eating, the participants eat vegetable bouillon (1,3g) |
|
| Microalgae phaeodactylum | Active Comparator | 14 days wahs-out: no fish eating 14 days: no fish eating, the participants eat vegetable bouillon (1.3g), 2.3g Microalgae Phaeodactylum |
|
| Beta-Glucan | Active Comparator | 14 days wahs-out: no fish eating 14 days: no fish eating, the participants eat vegetable bouillon (1.3g), Beta-Glucan (1.8g) |
|
| Combi Microalgae phaeodacytlum and Beta-Glucan | Active Comparator | 14 days wahs-out: no fish eating 14 days: no fish eating, the participants eat vegetable bouillon (1.3g), 2.3g Microalgae, Beta-Glucan (1.8g) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo vegetable bouillon | Dietary Supplement | 14 days wahs-out: no fish eating 14 days: no fish eating, the participants eat vegetable bouillon (1,3g) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in omega-6/omega-3 ratio (plasma level basis) | fatty acid chromatographic measurement | 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Omega-3 fatty acid index | fatty acid chromatographic measurement in red blood cells | 14 days |
| Uptake of fucoxanthin and beta-carotene | chromatographic measurement in plasma |
| Measure | Description | Time Frame |
|---|---|---|
| Markers for oxidative stress | lipid hydroperoxides) | 14 days |
| Albumin | Measurement in serum | 14 days |
Inclusion Criteria:
Age ≥60 ≤90 years, weight ≥50 kg, generally healthy
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Stephan C Bischoff, Prof. Dr | Contact | 0711 459 24101 | bischoff.stephan@uni-hohenheim.de | |
| Lena Stiefvatter, M.SC | Contact | 071145924881 | lena.stiefvatter@uni-hohenheim.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stephan C. Bischoff, Prof. Dr | Recruiting | Stuttgart | Baden-Wurttemberg | Germany |
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4 arm parallel groups
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| microalgae phaeodactylum | Dietary Supplement | 14 days wahs-out: no fish eating 14 days: no fish eating, the participants eat vegetable bouillon (1.3g), 2.3g Microalgae Phaeodactylum |
|
| From the Microalgae phaeodactylum the extracted beta-Glucan (especially chrysolaminarin) | Dietary Supplement | 14 days wahs-out: no fish eating 14 days: no fish eating, the participants eat vegetable bouillon (1.3g), Beta-Glucan (1.8g) |
|
| A combination of the vegetable bouillon, the microalgae and the beta-Glucan | Dietary Supplement | 14 days wahs-out: no fish eating 14 days: no fish eating, the participants eat vegetable bouillon (1.3g), 2.3g Microalgae, Beta-Glucan (1.8g) |
|
| 14 days |
| Inflammation (CRP) | measurement in blood serum | 14 days |
| weight | in kilograms | 14 days |
| FFQ- Food frequence questionnaire | Food questionnaire about the general eating of the last 4 weeks | 4 weeks |
| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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