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Older adults demonstrate increased distractibility by task-irrelevant information which contributes to general cognitive impairment. However, it is yet unclear how changes in noradrenergic activity during aging influences attentional control. In the current study, tonic noradrenergic activity will be increased or decreased to investigate its behavioral and neural effects on attentional control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Young Adults | Young Adults aged 18-35 | ||
| Older Adults | Older Adults aged 50-80 |
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| Measure | Description | Time Frame |
|---|---|---|
| Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker | The oculomotor suppression effect is a lower likelihood that salient display items will be the target of the initial eye movement in a visual search task compared to nonsalient display items. This effect is calculated from the percentage of first saccades toward a non-target stimuli subtracted by the percentage of first saccades toward the distractor stimuli. Greater % of first saccades toward the target would demonstrate better goal-directed attentional control and greater % of first saccades toward the distractor would demonstrate increased distractibility. Thus, a greater oculomotor suppression effect would demonstrate an increased ability to inhibit salient information that is irrelevant to the task. | Calculated once at the end of the 1 day experiment |
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Inclusion Criteria:
Exclusion Criteria:
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Young adults will be recruited from the student population at the University of Southern California. Older adults will be recruited from a volunteer registry.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| USC Leonard Davis School of Gerontology | Los Angeles | California | 90089 | United States |
At the conclusion of the study, data in de-identified form will be shared using the Open Science Framework and/or OpenNeuro Databases which are free and open platforms for sharing and archiving scientific data.
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Data will be made available at the end of the experiment, indefinitely.
Data will be uploaded to scientific data archiving platforms.
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| ID | Title | Description |
|---|---|---|
| FG000 | Young Adults | Young Adults aged 18-30 |
| FG001 | Older Adults | Older Adults aged 50-80 |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Young Adults | Young Adults aged 18-30 |
| BG001 | Older Adults | Older Adults aged 50-80 |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Customized | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker | The oculomotor suppression effect is a lower likelihood that salient display items will be the target of the initial eye movement in a visual search task compared to nonsalient display items. This effect is calculated from the percentage of first saccades toward a non-target stimuli subtracted by the percentage of first saccades toward the distractor stimuli. Greater % of first saccades toward the target would demonstrate better goal-directed attentional control and greater % of first saccades toward the distractor would demonstrate increased distractibility. Thus, a greater oculomotor suppression effect would demonstrate an increased ability to inhibit salient information that is irrelevant to the task. | Both young and older adults completed the experiment at baseline and under increased arousal (order counterbalanced). | Posted | Mean | Standard Error | percentage of first saccades | Calculated once at the end of the 1 day experiment |
|
Adverse events were monitored for one day during when the subject came into the lab to complete the experiment.
The intervention has minimal risk and expect no serious adverse events or mortality.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Young Adults | Young Adults aged 18-30 | 0 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Andy Kim | University of Southern California | 213-740-5156 | andyk@usc.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Sep 3, 2024 | Sep 3, 2024 | Prot_SAP_000.pdf |
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| BG002 |
| Total |
Total of all reporting groups |
| Participants |
|
| Sex/Gender, Customized | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| Young Adults Baseline |
Young adults aged 18-30 under no intervention |
| OG001 | Older Adults Basline | Older adults aged 50-80 under no intervention |
| OG002 | Young Adults + Arousal | Young adults aged 18-30 years older during the threat of shock block |
| OG003 | Older Adults + Arousal | Older adults aged 50-80 years older during the threat of shock block |
|
|
| 70 |
| 0 |
| 70 |
| 0 |
| 70 |
| EG001 | Older Adults | Older Adults aged 50-80 | 0 | 70 | 0 | 70 | 0 | 70 |
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