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9 general practices in the Netherlands were provided with two composite resin adhesives, each for a period of 9 months. One contained MDPB (Adhesive P), and the other one was used as a control (Adhesive S). Patient's age, SES, and caries risk, as well as tooth type/number, reason for restoration placement, used restorative material and bonding agent, and affected surfaces were recorded. All interventions carried out on these teeth in the next 6 years were extracted from the electronic patient records, along with their date, type, reason, and surfaces. Two dependent variables were defined: general failure, and failure due to secondary caries. All data handling and statistical analyses were carried out in R 4.0.5.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Protect Bond | Restoration placed using Clearfil Protect Bond adhesive (Kuraray Noritake, Osaka, Japan) , which contains the antibacterial monomer MDPB (12-Methacryloyloxydodecylpyridiniumbromide) |
| |
| SE Bond | Restoration placed using Clearfil SEBond adhesive (Kuraray Noritake, Osaka, Japan) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clearfil Protect Bond | Drug | An adhesive is used routinely when placing resin composite restorations. This group receives a commercially available adhesive containing an antibacterial monomer (MDPB) |
| Measure | Description | Time Frame |
|---|---|---|
| Restoration survival | Time in years restoration has survived without needing dental re-intervention | up to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Failure through caries | Incidence of secondary caries leading to replacement of the restoration | up to 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who visited one of the participating general dental practices during the study period needing at least one dental restoration
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37394389 | Derived | Hollanders ACC, Kuper NK, Bronkhorst EM, Laske M, Huysmans MCDNJM. Effectiveness of adhesive containing MDPB: A practice-based clinical trial. Dent Mater. 2023 Aug;39(8):756. doi: 10.1016/j.dental.2023.06.011. Epub 2023 Jul 1. |
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Anonimized data will be published in the DANS-easy archive. The study description are available to anyone, and the data are available upon request.
Data will become available upon study publication.
Any individual requesting access through the archive will obtain access
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| ID | Term |
|---|---|
| C503075 | Clearfil Protect Bond |
| C438313 | Clearfil SE Bond |
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|
| Clearfil SE Bond | Drug | An adhesive is used routinely when placing resin composite restorations. This group receives a commercially available adhesive. |
|