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This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection. Specifically, it is to analyze the outcome of the Infection Likely group and compare it to the Infection Unlikely group as well as other subgroups within previous validated definitions (Musculoskeletal Infection Society (MSIS)/International Consensus on Musculoskeletal Infection (ICM) 2013 and ICM 2018).
Periprosthetic joint infection (PJI) is a major burden for healthcare systems. The European Bone and Joint Infection Society (EBJIS) proposed a new set of criteria introducing a three level 'traffic light' distinction: Infection Unlikely, Infection Confirmed but also an intermediate group called Infection Likely (but nor confirmed). This retrospective multi-center, multi-national cohort study is to validate the EBJIS Definition of Prosthetic Joint Infection. Specifically, it is to analyze the outcome of the Infection Likely group and compare it to the Infection Unlikely group as well as other subgroups within previous validated definitions (Musculoskeletal Infection Society (MSIS)/International Consensus on Musculoskeletal Infection (ICM) 2013 and ICM 2018).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| revision total hip or knee arthroplasties | THA/TKA patients that underwent revision surgery between 01.01.2013 until 31.12.2018 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| data collection to classify infection status | Other | Review of medical records of all selected cases (TKA/THA patients) to classify infection status according to different classifications (EBJIS, MSIS/ICM 2013, ICM 2018). |
| Measure | Description | Time Frame |
|---|---|---|
| Prosthetic Joint Infections (with or without the need for further surgery) | Number of Prosthetic Joint Infections (with or without the need for further surgery) among each PJI definition ("Infection Unlikely", "Infection Confirmed", "Infection Likely (but nor confirmed)" | since 01.01.2013 with a minimum of two years follow up |
| Prosthetic Joint Infections (with or without the need for further surgery) | Number of Prosthetic Joint Infections (with or without the need for further surgery) according to different classifications (EBJIS, MSIS/ICM 2013, ICM 2018). | since 01.01.2013 with a minimum of two years follow up |
| Need for Revision Surgery | Number of Revision Surgeries (for all causes, PJI and aseptic failure) among each PJI definition ("Infection Unlikely", "Infection Confirmed", "Infection Likely (but nor confirmed)" | since 01.01.2013 with a minimum of two years follow up |
| Need for Revision Surgery | Number of Revision Surgeries (for all causes, PJI and aseptic failure) according to different classifications (EBJIS, MSIS/ICM 2013, ICM 2018). | since 01.01.2013 with a minimum of two years follow up |
| Survival rates of different subgroups among each PJI definition | Survival rates of different subgroups among each PJI definition ("Infection Unlikely", "Infection Confirmed", "Infection Likely (but nor confirmed)" | since 01.01.2013 with a minimum of two years follow up |
| Survival rates between different definitions | Survival rates between different classifications (EBJIS, MSIS/ICM 2013, ICM 2018). |
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Inclusion Criteria:
Exclusion Criteria:
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THA/TKA patients that underwent revision surgery regardless of final aseptic vs. infected diagnosis between 1st of January 2013 until 31.12.2018. All data coming from everyday clinical work. The average patient operated with revision arthroplasty is normally aged above 70 years.
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| Name | Affiliation | Role |
|---|---|---|
| Ricardo Jorge Gomes de Sousa, Prof. Dr. med. | Centro Hospitalar Universitario do Porto, Orthopedics Department | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centro Hospitalar do Porto, Porto, Portugal | Porto | 4099-001 | Portugal | |||
| University Hospital Basel, Orthopedics and Traumatology |
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| since 01.01.2013 with a minimum of two years follow up |
| Basel |
| 4031 |
| Switzerland |