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Arthroscopic partial meniscectomy(APM) surgery outcomes for Metabolic Syndrome(MetS) patients with degenerative meniscus tears(DMTs) was still not clear. The aim of the study was to investigate outcomes of early APM vs delayed APM for MetS patients with degenerate meniscus tears.
Degenerate meniscus tears(DMTs) were the most common knee disease in aged and obese people. The most common treatment for DMTs was arthroscopic partial meniscectomy(APM) surgery. However, the time window for performing APM surgery was unclear, especially in obese patients with Metabolic syndrome(MetS). Abdominal obesity, insulin resistance with or without glucose intolerance, dyslipidemia or elevated blood pressure are included in the principal components of MetS. Whether early APM within 3 to 6 months or delayed APM surgery within 6 to 12 months are benefical to MetS patients with DMTs. The knee function outcomes between early APM and delayed APM for MetS patients with DMTs were assessed and follow up to 12 months after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| early APM | Experimental | Early APM group were patients have knee syndrome within 3 to 6 months |
|
| delayed APM | Placebo Comparator | delayed APM group recruit participants who received delayed APM surgery within 6 to 12 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| early APM | Procedure | Early APM group were patients have knee syndrome within 3 to 6 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Knee KOOS score | The KOOS was a self-administered outcome questionnaire has been validated in individuals undergoing APM surgery,with 0(extreme knee problem) to 100 points(the best possible score, no knee problems) | up to 12 month |
| IKDC score | The IKDC was a questionnaire that has high reliability and validity for middle to older patients with a meniscal tear,with 0(extreme knee problem) to 100 points(the best possible score, no knee problems) | up to 12 month |
| waist circumstance | midway between the lowest rib and the iliac crest, using an anthropometric tape | at baseline |
| SBP | systolic blood pressure | at baseline |
| DBP | diastolic blood pressure | at baseline |
| TC | serum total cholesterol (TC) | at baseline |
| TG | serum triglycerides (TG) | at baseline |
| LDL | serum low-density lipoprotein cholesterol (LDL-C) | at baseline |
| Measure | Description | Time Frame |
|---|---|---|
| pain score | The KOOS subscales for pain,with 0(extreme knee problem) to 100 points(the best possible score, no knee problems) | up to 12 month |
| symptoms score | The KOOS subscales for symptoms,with 0(extreme knee problem) to 100 points(the best possible score, no knee problems) |
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Inclusion Criteria:
• Must be age between 35 and 70 years old;
Exclusion Criteria:
Must be able to have no acute knee injury such as car crash or acute sports injury;
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yue Guo, Master | Contact | 13897830515 | 373073766@qq.com | |
| Zipeng Zhou, Master | Contact | 15841659784 | zhouzipeng1990@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Jinzhou Medical University | Recruiting | Jinzhou | Liaoning | 121000 | China |
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| delayed APM | Procedure | delayed APM group recruit participants who received delayed APM surgery within 6 to 12 months |
|
|
| HDL | serum high-density lipoprotein cholesterol (HDL-C) | at baseline |
| FBG | serum fast blood glucose(FBG) | at baseline |
| BMI | BMI, calculated as weight in kilograms divided by height in meters squaredBMI in kg/m^2 | at baseline |
| K-L grade | Kellgren-Lawrence (K/L) grade | at baseline |
| up to 12 month |
| activities of daily living score | The KOOS subscales for activities of daily living,with 0(extreme knee problem) to 100 points(the best possible score, no knee problems) | up to 12 month |
| function in sport and recreation score | The KOOS subscales for function in sport and recreation,with 0(extreme knee problem) to 100 points(the best possible score, no knee problems) | up to 12 month |
| knee related quality of life score | The KOOS subscales for knee related quality of life,with 0(extreme knee problem) to 100 points(the best possible score, no knee problems) | up to 12 month |