Sleep Disorders in Idiopathic Pulmonary Fibrosis

Sleep Disorders in Idiopathic Pulmonary Fibrosis

This diagnostic observational study was conducted to (1) investigate the prevalence of sleep-related breathing disorders and other sleep disorders in idiopathic pulmonary fibrosis in comparison to COPD, (2) identify characteristics of symptomatic and prognostic significance in idiopathic pulmonary fibrosis with/without sleep disorders, and (3) evaluate different tools for their ability to assess the risk of co-existing sleep disorders in idiopathic pulmonary fibrosis.

Inclusion Criteria:

• Age >=18 years
• written informed consent
• IPF cohort: Documented history of IPF with definite or possible UIP pattern and signs of emphysema below 10% by HRCT (IPF diagnosis according to 2011 ATS/ERS IPF guidelines)
• COPD cohort: Documented history of COPD Stage II Group A or B, Stage III or IV, Group C or D (GOLD 2014)

Exclusion Criteria:

• Long-term oxygen therapy
• Heart failure NYHA stages III and IV
• Left ventricular ejection fraction ≤ 45%
• Pregnancy and/or lactation
• Acute and/or life-threatening illness (instable angina pectoris, acute pulmonary arterial embolism, myocardial infarction, malignant tumor requiring treatment)
• Current drug or alcohol abuse
• Any medical, psychological or other condition impairing the patient's ability to provide informed consent
• IPF cohort: Acute exacerbation of IPF
• IPF cohort: Concomitant lung/airway diseases other than IPF (signs of emphysema >10% by HRCT)
• COPD cohort: Acute exacerbation of COPD
• COPD cohort: Concomitant lung/airway diseases other than COPD (e.g. Asthma bronchiale)
• Healthy cohort: Documented history of structural airway or lung disease