The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding

The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding: Prospective Randomized Controlled Trial

Determine the effect of high-dose pancreatic enzyme supplementation on nutritional indicators and clinical course in critically ill patients undergoing enteral nutrition.

Inclusion Criteria:

• Adults 19 years and older

• Hospitalized in the surgical/medical intensive care unit of the Seoul National University Hospital

• Enteral nutrition

• Patients who consented to this study

• Patients with risk factors for pancreatic exocrine dysfunction

  • Shock (Norepinephrine)
  • Sepsis (3 rd definition of sepsis)
  • Diabetes
  • Cardiac arrest
  • hyperlactatemia serum lactate > 2 mmol/L)
  • Mechanical ventilation
  • Continuous renal replacement therapy

Exclusion Criteria:

• chronic pancreatitis

• unresectable pancreatic cancer

• History of pancreatectomy

• Underlying diseases in which the effect of Exocrine pancreatic enzyme administration is difficult to show

  • Inflammatory bowel disease
  • Short bowel syndrome