to analyze if a probe strategy choice for PGT-SR studies of Robertsonian translocations (RT) influences the fate of embryos? Few studies discussed the importance of probe choices. However, those who did, demonstrated that analysis with locus specific probes improve a diagnosis of dubious results, and addition of a centromeric probe could affect the accuracy of diagnosis

Inclusion criteria:

• Adult patient whom carrying robertsonian translocations in the context of PGT-SR management
• age > 18 years

Exclusion criteria:

- age < 18 years

Robertsonian translocation carriers are phenotypically normal, but they are known to be at increased risk of repeated miscarriages compared with the general population estimated at about 15% of pregnancies, and also resulting in the birth of a child with congenital anomalies or a mental retardation.

NC