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Pancreatico-duodenectomy is one of the commonly performed procedure for periampullary/distal cholangio/head of pancreas carcinoma. Post operative pancreatitis is an emerging concept, recently being studied as one of the most important contributing factor of Post-operative pancreatic fistula, which is one of the major complication of pancreatoduodenectomy. Rectal indomethacin, a type of non-steroidal anti-inflammatory drug, when given in a single dose has been shown to prevent pancreatitis in patients undergoing ERCP. In this study, we will be administering rectal indomethacin at the time of induction of anesthesia to the experimental arm of the study and compare the results in terms of incidence of post-operative pancreatitis in the two groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group B | Active Comparator | Standard Medical Treatment |
|
| Group A | Experimental | Will be administered 100mg of Indomethacin Suppository sigle dose at the time of induction of anesthesia with Standard Medical Treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Indomethacin suppository | Drug | 100mg Indomethacin Suppository administered at the time of Induction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Post-operative Pancreatitis | first 30 days following pancreatoduodenectomy |
| Measure | Description | Time Frame |
|---|---|---|
| Post-operative Pancreatic Fistula | first 30 days following pancreatoduodenectomy | |
| delayed gastric emptying | First 30 days following pancreatoduodenectomy | |
| intra-abdominal abscess |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Viniyendra Pamecha, FEBS | Institute of Liver & Biliary Sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Liver & Biliary Sciences | New Delhi | National Capital Territory of Delhi | 110070 | India |
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| Standard Medical Treatment | Other | Standard Medical Treatment |
|
| first 30 days following pancreatoduodenectomy |
| Length of ICU stay | First 30 days following pancreatoduodenectomy |
| Length of hospital stay | First 30 days following pancretoduodenectomy |
| risk factors of post-operative pancreatitis | first 30 days following pancreatoduodenectomy |