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The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact of elevated oxidative stress on this associations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NT group - normotensive children | |||
| HT group - hypertensive children |
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| Measure | Description | Time Frame |
|---|---|---|
| Systemic microvascular function in children | Skin microvascular reactivity assessed by Laser Doppler flowmetry (post-occlusive reactive hyperemia, iontophoresis of acetylcholine and sodium nitroprusside) - measured in perfusion units (PU) | Day 1. |
| Systemic macrovascular function in children | Vascular ultrasound measurement of brachial artery response to vascular occlusion (flow mediated dilation; FMD, %) | Day 1. |
| Cerabral vascular function in children | Cerebral blood flow velocities assessed by transcranial Doppler sonography (cm/s) | Day 1. |
| Measure | Description | Time Frame |
|---|---|---|
| Oxidative stress - thiobarbituric acid reactive substances (TBARS) | Serum sample collection for measurement of biomarkers of oxidative stress level. Thiobarbituric acid reactive substances (TBARS) - biomarker of lipid peroxidation. | Day 1. |
| Endocan |
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure | Automatic oscillometric measurement of blood pressure (in mmHg) | Day 1. |
| Heart rate | Automatic oscillometric measurement of heart rate (bpm) |
Inclusion Criteria:
Exclusion Criteria:
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children aged 9-18 years of both sexes; normotensive and children with essential arterial hypertension
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Martina Kos, MD | Contact | +385981748381 | mkatic983@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Martina Kos, MD | Osijek University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Osijek University Hospital | Recruiting | Osijek | 31000 | Croatia |
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| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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Serum sample collection for ELISA measurement of serum endocan level - proteoglycan associated with endothelium activation
| Day 1. |
| Day 1. |
| Body mass index | Measurement of body weight (kg) and body height (cm) from which will be combined to report body mass index (BMI) using formula: weight (kg) / [height (m)]2 (kg/m2) | Day 1. |
| Body composition - Fat Free Mass estimation | Body composition status measured by a fourterminal portable impedance analyzer. Based on the value of skin resistance (Ohm) empirically dervide formulas (the original manufacturer's software) will be used to calculate the estimated Fat Free Mass (FFM kg) | Day 1. |
| Body composition - Fat estimation | Body composition status measured by a fourterminal portable impedance analyzer. Based on the value of skin resistance (Ohm) empirically dervide formulas (the original manufacturer's software) will be used to calculate the estimated Fat (Fat Mass kg) | Day 1. |
| Body fluid status | Body fluid status measurement by a four-terminal portable impedance analyzer. Based on the value of skin resistance (Ohm) empirically derived formulas (the original manufacturer's software) will be used to calculate the estimated Total Body Water (TBW L), Extracellular Water (ECW L), Intracellular Water (ICW L), Plasma Fluid (PF L) and Interstitial Fluid (IF L). | Day 1. |