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Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.
Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HOLEP | Active Comparator | Patients with a prostate volume greater than 80 g |
|
| TURP | Active Comparator | Patients with a prostate volume less than 80 g |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgery method | Procedure | Patients were subdivided into two groups according to their prostate volume |
|
| Measure | Description | Time Frame |
|---|---|---|
| inflamatory markers | WBC (109 /L) | Change from baseline WBC (109 /L) at postoperative 0th and postoperative 24th hour |
| Stress hormone levels | Adrenaline (ng/L) | Change from baseline adrenaline (ng/L) at postoperative 0th and postoperative 24th hour |
| inflamatory markers | CRP | Change from baseline CRP (mg/L) at postoperative 0th and postoperative 24th hour |
| inflamatory markers | IL-6 (pg/ml) and TNF-alfa (pg/ml) | Change from baseline IL-6 (pg/ml) and TNF-alfa (pg/ml), at postoperative 0th and postoperative 24th hour |
| inflamatory markers | CD4+/CD8+ | Change from baseline CD4+/CD8+ at postoperative 0th and postoperative 24th hourL-6 (pg/ml) and TNF-alfa (pg/ml) |
| stress hormone levels | Cortisol (microg/dl) | Change from baseline cortisol (microg/dl) at postoperative 0th and postoperative 24th hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Baris Arslan, MD | Adana City Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Adana City Training and Research Hospital | Adana | 01170 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D011470 | Prostatic Hyperplasia |
| ID | Term |
|---|---|
| D011469 | Prostatic Diseases |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| D052801 |
| Male Urogenital Diseases |