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The aim of study is to compare the evaluation of dark halo area of macular neovascularization (MNV) between indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) in order to identify OCTA as effective and useful biomarker in MNV
Dark halo is defined as a dark perilesional of flow decrease due to an area of reduced choroidal flow adjacent to the macular neovascularization (MNV).
The detection of MNV vascular details was only possible through invasive dye injection, such as fluorescein angiography (FA) or indocyanine green angiography (ICGA).
Optical coherence tomography angiography (OCTA) is a recent imaging technique that is able to detect the perfusion and non-perfusion areas carefully.
The aim of study is to compare the evaluation of dark halo area of MNV between ICGA and OCTA
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MNV group | Eyes affected by MNV. The dark halo of MNV was evaluated by OCTA and ICGA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optical Coherence Tomography Angiography (OCTA) and indocyanine green angiography (ICGA) | Diagnostic Test | OCTA and ICGA is able to detect the dark halo as a area of reduced perfusion around MVN |
| Measure | Description | Time Frame |
|---|---|---|
| Dark halo measurement | The OCTA and ICGA parameters analyzed are: the area of dark halo (mm2) that surrounds the coroidal neovascularization. | three years |
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Inclusion Criteria:
Exclusion Criteria:
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A group of patients affected by MNV is subjected to OCTA and ICGA analysis in order to evaluate which of two methods is able to detect in a peculiar way the dark halo around the MNV
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| Name | Affiliation | Role |
|---|---|---|
| Gilda Cennamo | Università Federico II | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Naples "Federico II" | Naples | 80100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35522297 | Derived | Fossataro F, Cennamo G, Montorio D, Clemente L, Costagliola C. Dark halo, a new biomarker in macular neovascularization: comparison between OCT angiography and ICGA-a pilot prospective study. Graefes Arch Clin Exp Ophthalmol. 2022 Oct;260(10):3205-3211. doi: 10.1007/s00417-022-05693-8. Epub 2022 May 6. |
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