Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).

Inclusion Criteria:

• Age Limits (18-80 years)
• Information and non-opposition for participating in the study
• Patients suffering from periodontitis grade III ou IV
• Patients suffering from microcristalline arthritis
• patient with health insurance

Exclusion Criteria:

• patient under corticotherapy
• pregnancy
• non-compliant patient
• patient with no health insurance
• patient in exclusion period from an other study
• legal incapacity

patients are anonymized