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| Name | Class |
|---|---|
| Bursa Yuksek Ihtisas Training and Research Hospital | OTHER_GOV |
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Multiple pregnancies are associated with increased maternal and fetal risks compared to singleton pregnancies. Additionally, the cesarean section rate is quite high in multiple pregnancies. This study aimed to evaluate maternal and fetal characteristics and factors affecting fetal outcomes in twin pregnancies delivered by cesarean section.
While the frequency of multiple pregnancies varies significantly among societies and individuals, especially in middle and high-income countries, the rate of multiple pregnancies has shown a significant rise worldwide in recent years, with the frequent use of assisted reproductive techniques, which has increased due to an increase in maternal age and a decrease in fertility. As a result, multiple pregnancies constitute approximately 2-4% of all births.
Multiple pregnancies are known to be associated with increased maternal and fetal risks compared to singleton pregnancies. While maternal mortality associated with a twin pregnancy is 2.5 times higher than in singleton pregnancy, adverse neonatal outcomes such as perinatal mortality, fetal growth restriction, and low birth weight are two to three times higher in twins than in singleton newborns. Moreover, neonatal near-miss, which refers to cases that almost resulted in death, is associated with multiple pregnancies.
For all these reasons, the planned cesarean section has been advocated over planned vaginal delivery to reduce the risk of adverse neonatal outcomes (especially for the second-born twin). However, cesarean delivery is known to be associated with a higher risk of maternal morbidity and poor neonatal outcomes. The vast majority of these risks are related to maternal hypotension, prolonged uterine-incision-to-delivery time, and general anesthesia. From this perspective, we aimed to evaluate maternal and fetal characteristics and factors affecting fetal outcomes in twin pregnancies delivered by cesarean section.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Twin neonates | The demographic data and characteristics of the twins were evaluated. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spinal anesthesia | Procedure | Twins delivered under under spinal anesthesia |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Appearance-Pulse-Grimace-Activity-Respiration-1st minute (worst:0; best:10) | Appearance-Pulse-Grimace-Activity-Respiration (APGAR) score at the 1st minute after delivery | 1 minute |
| Appearance-Pulse-Grimace-Activity-Respiration-5th minute (worst:0; best:10) | Appearance-Pulse-Grimace-Activity-Respiration (APGAR) score at the 5th minute after delivery | 5 minute |
| The Number of Participants Admitted to Neonatal Intensive Care Unit | Admission to Neonatal Intensive Care Unit after delivery | 1 hour |
| The Number of Participants needed for Mechanical ventilation | The need for non-invasive and invasive mechanical ventilation | 28 days |
| The Rate of Death | Neonatal mortality within the first 28 days after birth. | 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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The twin newborns were delivered by cesarean section.
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| Name | Affiliation | Role |
|---|---|---|
| Hande Gurbuz, Assoc. Prof. | Bursa Yuksek Ihtisas Training and Research Hospital | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22713496 | Result | Young BC, Wylie BJ. Effects of twin gestation on maternal morbidity. Semin Perinatol. 2012 Jun;36(3):162-8. doi: 10.1053/j.semperi.2012.02.007. | |
| 30231294 | Result | Santana DS, Surita FG, Cecatti JG. Multiple Pregnancy: Epidemiology and Association with Maternal and Perinatal Morbidity. Rev Bras Ginecol Obstet. 2018 Sep;40(9):554-562. doi: 10.1055/s-0038-1668117. Epub 2018 Sep 19. |
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Individual, de-identified participant data will be shared with the researchers who provide a methodologically sound proposal.
Beginning nine months following a possible publication and ending after one year.
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| ID | Term |
|---|---|
| D000775 | Anesthesia, Spinal |
| D000768 | Anesthesia, General |
| ID | Term |
|---|---|
| D000765 | Anesthesia, Conduction |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
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| General anesthesia |
| Procedure |
Twins delivered under general anesthesia |
|
| 27599496 | Result | Cheong-See F, Schuit E, Arroyo-Manzano D, Khalil A, Barrett J, Joseph KS, Asztalos E, Hack K, Lewi L, Lim A, Liem S, Norman JE, Morrison J, Combs CA, Garite TJ, Maurel K, Serra V, Perales A, Rode L, Worda K, Nassar A, Aboulghar M, Rouse D, Thom E, Breathnach F, Nakayama S, Russo FM, Robinson JN, Dodd JM, Newman RB, Bhattacharya S, Tang S, Mol BW, Zamora J, Thilaganathan B, Thangaratinam S; Global Obstetrics Network (GONet) Collaboration. Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ. 2016 Sep 6;354:i4353. doi: 10.1136/bmj.i4353. |
| 22855972 | Result | National Collaborating Centre for Women's and Children's Health (UK). Multiple Pregnancy: The Management of Twin and Triplet Pregnancies in the Antenatal Period. London: RCOG Press; 2011 Sep. Available from http://www.ncbi.nlm.nih.gov/books/NBK83105/ |
| 37222324 | Derived | Kilicarslan N, Gurbuz H, Tasgoz FN, Karaca U, Karasu D, Gamli M. Factors influencing neonatal outcomes in twin pregnancies undergoing cesarean section: a cross-sectional study. Rev Assoc Med Bras (1992). 2023 May 19;69(5):e20221464. doi: 10.1590/1806-9282.20221464. eCollection 2023. |