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| Name | Class |
|---|---|
| National Health Research Institutes, Taiwan | OTHER |
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The purpose of this project is:
Detailed Description:
Investigators plan to use a stepped-wedge cluster randomized trial that allocates participants into the following three groups:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Screening group | Experimental | Inform the elderly about the results of the screening and recommend those with moderate to high risk of fracture to receive active examination and treatment. |
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| Multi-component integrated intervention | Experimental | Introduce integrated services of health education, nutrition, rehabilitation, pharmaceutical care, and other multi-specialties to assist study participants with health promotion |
|
| Delayed intervention | Placebo Comparator | receive general care after collecting basic information, and provide health education related information such as osteoporosis sarcopenia. After two year's follow-up, multi-disciplinary team intervention service will be implemented. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Osteoporosis screening and treatment as needed | Behavioral | All residents underwent screening using the Fracture Risk Assessment Tool (FRAX) and Mobile dual-energy X-ray absorptiometry (DXA) (Horizon Wi, Hologic Inc., Bedford, MA). Our study nurses actively assisted osteoporosis treatment if indicated. |
| Measure | Description | Time Frame |
|---|---|---|
| The changes of Quality of life and quality adjusted life year | Using EQ5D / WHOQOL Brief questionnaires to measure quality of life and evaluate the changes after intervention. In addition, to calculate quality adjusted life year by using utility index derived from qualify of life measurement. | one year, two year, 3 year, four year |
| Intrinsic capacity | To define if the Intrinsic capacity would be changed after intervention | one year, two year, 3 year, four year |
| Institutionalilzation rate | To define if the Institutionalilzation rate would be changed after intervention | one year, two year, 3 year, four year |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of fall | To define if the fall frequency would be changed after intervention | one year, two year, 3 year, four year |
| Incidence of fracture | To define if the incidence of fracture would be changed after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of mortality | To define if the Incidence of mortality would be changed after intervention | one year, two year, 3 year, four year |
| Changes of drug related problems | Under the assumption of the intervention of pharmaceutical care in the multi-component group can improve the DRPs of the elderly, we also measured the changes of drug number, anticholinergic burden and adherence (using the Adherence to Refills and Medications Scale). |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shau-Huai Fu, Doctor | Contact | +886972655734 | b90401045@gmail.com | |
| Chen-Yu Wang, Doctor | Contact | +886952489782 | valinawang0220@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital, Yunlin branch | Recruiting | Douliu | Yunlin County | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39875677 | Derived | Fu SH, Lai WJ, Yen HK, Kukreti S, Li CY, Hung CC, Wang CY. Addressing healthcare disparities and improving osteoporosis management in rural communities: a cluster randomized control trial. Arch Osteoporos. 2025 Jan 28;20(1):15. doi: 10.1007/s11657-025-01498-4. |
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|
| Sarcopenia | Behavioral | Sarcopenia assessment adhered to the 2019 Consensus Update on Sarcopenia Diagnosis and Treatment by the Asian Working Group for Sarcopenia guideline. Following screening, individuals identified with sarcopenia underwent tailored interventions involving exercise and nutrition as deemed necessary. |
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| Exercise | Behavioral | TheraBand (resistance band) was utilized as the exercise tool within the community. T |
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| Nutrition | Dietary Supplement | Nutrition Nutritional education programs aim to increase protein food serving and the choice of those with insufficient dietary intake. Protein supplement was added if indicated. |
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| Pharmaceutical care | Behavioral | We collected drug information of the elderly. Detailed and real-time prescription drug information was retrieved from the National Health Insurance PharmaCloud System. A pharmaceutical care team performed patient-centered drug review and discussion every three to six months. |
|
| one year, two year, 3 year, four year |
| Incidence of unexpected hospitalization | To define if the unexpected hospitalization would be changed after intervention | one year, two year, 3 year, four year |
| one year, two year, 3 year, four year |
| Phyiscal performance | Changes of muscle strength, body composition, physical performance, activites of daily living | one year, two years |
| Sarcopenia related outcomes | We follow sarcopenia diagnosis rate, treatment rate, changes of muscle mass, fat, and muscle-fat index | one year, two years |
| Osteoporosis related outcomes | We follow osteoporosis diagnosis rate, treatment rate, adherence to osteoporosis treatment, and changes of bone mineral density | one year, two years |
| Mental health | We use Geriatric Depression Scale and Chinese Happiness Inventory to measure depression and happiness | one year, two years |
| Nutrition related outcomes | Changes in protein intake, dietary/caloric intake, nutritional status | one year, two years |
| Cognition | Changes in MMSE | one year, two years |
| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| D055948 | Sarcopenia |
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D006301 | Health Services Needs and Demand |
| D015444 | Exercise |
| D009752 | Nutritional Status |
| D010593 | Pharmaceutical Services |
| ID | Term |
|---|---|
| D006302 | Health Services Research |
| D006285 | Health Planning |
| D004472 | Health Care Economics and Organizations |
| D003695 | Delivery of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D006304 | Health Status |
| D003710 | Demography |
| D011154 | Population Characteristics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
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