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| Name | Class |
|---|---|
| Odense University Hospital | OTHER |
| Aalborg University Hospital | OTHER |
| Bispebjerg Hospital | OTHER |
| Herlev and Gentofte Hospital |
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Mechanical ventilation is likely lifesaving in patients with coronavirus disease 2019 (COVID-19) but may also result in adverse events. Only few studies describe the strategies used and adverse effect of mechanical ventilation in an unselected population of ICU patients with COVID-19.
This study is designed to be a retrospective study focusing on all mechanical ventilated ICU patients with COVID-19 included in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e. a total of 1,193 patients. The investigators will register the use of the core interventions around mechanical ventilation and its potential adverse event, including barotrauma and prolonged ventilation.
This study will provide important data on the ventilation strategies used and its potential adverse events in unselected ICU patients with COVID-19 and thereby inform clinicians, patients, policy-makers, and future research in this area.
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| Measure | Description | Time Frame |
|---|---|---|
| Ventilator days with lung -protective ventilation in percent of all ventilation days with 95%-CI. | Low tidal volume ventilation (Vt 4-8 mL/kg of predicted body weight) | Until 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Pneumothorax | Pneumothorax noted in the medical record | Until 90 days |
| Ventilator days | Number of days where the patients where the patient is ventilator depended |
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Inclusion Criteria:
All mechanical ventilated patients registered in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e.
Exclusion Criteria:
None
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All mechanical ventilated patients registered in the national Danish COVID ICU database
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anne C Brøchner, MD, Ph D | Contact | +4529464468 | anne.craveiro.broechner@rsyd.dk | |
| Nikolai arnold-larsen, MD | Contact | nikolai.arnold-larsen@rsyd.dk |
| Name | Affiliation | Role |
|---|---|---|
| Anne C Brøchner, MD, PhD | University of Southern Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesiology and Intensive Care Medicine, Aalborg University Hospital | Recruiting | Aalborg | 9000 | Denmark |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| OTHER |
| Hvidovre University Hospital | OTHER |
| Rigshospitalet, Denmark | OTHER |
| Aarhus University Hospital | OTHER |
| Region Zealand | OTHER |
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| Until 90 days |
| Number of patients with prolonged ventilation | Patients with more than 30 ventilator days | Until 90 days |
| paO2/FiO2 ratio on days of ventilation | Ratio between measured arterial oxygen pressure and the fraction of inhaled oxygen | Until 90 days |
| The use of APRV | The use of Airway pressure release as primary ventilator setting | Until 90 days |
| Prone position | The use of prone position within the first 3 days and the use of prone position after day 3 | Until 90 days |
| Time to spontaneous ventilation | Time measured in days until the patients no longer needs controlled ventilation | Until 90 days |
| Tracheostomy | Day after first intubation, Percutaneous dilatational tracheostomy (y/n), Surgical tracheostomy (y/n) | Until 90 days |
| Adjuvant drugs | Adjuvant drugs at any time during mechanical ventilation | Until 90 days |
| Mortality | Mortality at day 90 | Until 90 days |
| Department of Anesthesiology and Intensive Care, Kolding Hospital | Recruiting | Kolding | 6000 | Denmark |
|
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |