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Mold allergies are becoming increasingly important among the population. Increasing amounts of fungal spores are analyzed in air-samples because of urbanization, industrialization of food products and climate change. Mold also grows indoor and hence lead to additional health complaints.
Alternaria alternata, and its only major allergen Alt a 1, is the most important fungus for allergy sufferers. Alternaria alternata can not only cause allergic symptoms but can also cause intensified asthmatic symptoms.
Besides Alternaria alternata, there are over 700 other species of the genus Alternaria. The influence of these other species on allergic symptoms is poorly understood.
Furthermore, prevalence and incidence of an allergy to Alternaria alternata among the Austrian population is not known. Estimates range between 1-5% among the Austrian population.
This study aims to further investigate the incidence and characteristics of an allergy to Alternaria in Austria. This will be investigated with the help of participants (50 Alternaria allergy sufferers and 20 non allergic participants), spore counts in Austria and crowd-sourced symptom data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alternaria allergy sufferers | 50 people suffering from an allergy to Alternaria. These participants receive a questionnaire, a Skin-Prick-Test, a blood draw and nasal provocation with collection of nasal secretion |
| |
| Non-allergic participants | Non allergic participants (20) receive a questionnaire, a blood draw and collection of nasal secretion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nasal provocation | Diagnostic Test | Nasal provocation with Alternaria alternata extract. Changes in nasal mucosa are measured with a rhinomanometry device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence, Immunoglobulin-E (IgE)-antibodies to selected Alternaria species | Determine the prevalence of sensitization to multiple Alternaria species in the Austrian population | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Cytokine-profile (e.g. Interleukin-13, Interleukin-5, Interleukin-10, TNFalpha, IFNgamma) upon Alt a 1 incubation | Changes in the immun response when ligand-binding mononuclear cells from the blood to Alt a 1, characterized by the cytokine profile (Th1/Th2/regulatory) and the cell population (B- and T-cells, macrophages/monocytes) | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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Participants are recruited with the help of advertisements on the social media pages of the Austrian Pollen Information Service and on the pollen diary app
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Markus Berger, Dr. | Contact | +4369918939871 | markus.berger@meduniwien.ac.at |
| Name | Affiliation | Role |
|---|---|---|
| Erika Jensen-Jarolim, Univ.-Prof. Dr. | Department of Pathophysiology and Allergy Research | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Recruiting | Vienna | 1090 | Austria |
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| ID | Term |
|---|---|
| D006967 | Hypersensitivity |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D009299 | Nasal Provocation Tests |
| D010328 | Patch Tests |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012882 | Skin Tests |
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| Skin-Prick Test | Diagnostic Test | Skin-Prick-Test is administered to determine an allergy against Alternaria |
|
| Blood draw | Diagnostic Test | For further analysis |
|
| Collection of nasal secretion | Diagnostic Test | Allergy sufferers: After nasal provocation Non-allergics: After administration of isotonic nasal spray |
|
| D007159 | Immunologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D008919 | Investigative Techniques |
| D007158 | Immunologic Techniques |
| D013048 | Specimen Handling |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |