A Phase 3 Randomized, Open-Label Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
A Phase 3 Randomized, Open-Label Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria based on n positron emission tomography and computed tomography (PET/CT), and to compare the efficacy of zanubrutinib plus rituximab versus R^2 in participants with R/R marginal zone lymphoma (MZL), as measured by progression free survival (PFS) assessed by IRC in accordance with CT-based Lugano 2014 Criteria.
Our company, previously known as BeiGene, is now officially BeOne Medicines. Because some of our older studies were sponsored under the name BeiGene, you may see both names used for this study on this website.
Key Inclusion Criteria:
Key Exclusion Criteria:
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Fresno, California 93730-3595, United States
Baltimore, Maryland 21201, United States
Columbia, Missouri 65212-1000, United States
Caba, 1425, Argentina
Ciudad Autonoma Buenos Aires, 1413, Argentina
Botucatu, 18618687, Brazil
Ribeirão Preto, 14051-140, Brazil
Québec, Quebec G1J 1Z4, Canada
SaintJerome, Quebec J7Z 5T3, Canada
Beijing, Beijing Municipality 101100, China
Wuhan, Hubei 430022, China
Wuhan, Hubei 430030, China
Taian, Shandong 271099, China
Strasbourg, 67200, France
VandoeuvrelesNancy, 54511, France
KyotoShi, Kyoto 602-8566, Japan
Bunkyoku, Tokyo 113-8677, Japan
ChuoKu, Tokyo 104-0045, Japan
Kotoku, Tokyo 135-8550, Japan
VILA NOVA de GAIA Porto, 4434-502, Portugal
ClujNapoca, 400015, Romania
BusanjinGu, Busan Gwang'Yeogsi 47392, South Korea
BukGu, Gyeongsangbukdo 41404, South Korea
HwasunGun, Jeonnam-Gwangju S.M. City 58128, South Korea
GangnamGu, Seoul Teugbyeolsi 06351, South Korea
SeochoGu, Seoul Teugbyeolsi 06591, South Korea
SeodaemunGu, Seoul Teugbyeolsi 03722, South Korea
SongpaGu, Seoul Teugbyeolsi 05505, South Korea
YongsanGu, Seoul Teugbyeolsi 04401, South Korea
La ChauxdeFonds, 2300, Switzerland
AOCiftlii, 06560, Turkey (Türkiye)
Tevikiye, 34365, Turkey (Türkiye)
Greater Manchester, M20 4BX, United Kingdom