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The study aims to determine if genotype-based nutrition and lifestyle advice is effective for the management of overweight and obesity among Filipino adults compared to the usual standard of care.
The primary objective of the study is to determine if providing a nutrition and lifestyle advice with genetic information can promote the attainment of 5-10% weight loss, and improvements on body mass index, waist circumference, and body fat percentage among Filipino adults with overweight and obesity. Additionally, changes in dietary intake, eating behaviour, physical activity level, biochemical parameters (HbA1c and blood lipid profile), motivation for weight loss, and knowledge and perceptions on nutrigenomics and genetic testing will also be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MyGeneMyDiet® Recommendations for Weight Management | Experimental | A set of nutrition and lifestyle advice for weight management derived from genetic information |
|
| Usual Standard of Care for Weight Management | Active Comparator | A set of standard nutrition and lifestyle advice for weight management without genetic information |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MyGeneMyDiet® Recommendations for Weight Management | Genetic | This group will receive Nutrition and Lifestyle recommendation based on SNPs known to have an impact to body weight and body composition, and responses to physical activity and dietary fat intake |
| Measure | Description | Time Frame |
|---|---|---|
| 5% weight loss | Attainment of 5% weight loss | 24 weeks |
| 10% weight loss | Attainment of 10% weight loss | 48 weeks |
| Body mass index | Changes in BMI | 24 weeks |
| Waist circumference | Changes in waist circumference | 24 weeks |
| Body fat percentage | Changes in body fat percentage | 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Dietary intake | Improvements in dietary intake | 24 weeks |
| Eating behavior | Improvements in eating behavior | 24 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jacus S Nacis, MBAH | Department of Science and Technology-Food and Nutrition Research Institute (DOST-FNRI) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Science and Technology-Food and Nutrition Research Institute | City of Taguig | National Capital Region | 1631 | Philippines |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37674889 | Background | Nacis JS, Labrador JPH, Ronquillo DGD, Rodriguez MP, Dablo AMFD, Frane RD, Madrid ML, Santos NLC, Carrillo JJV, Fernandez MG, Gonzales GBL. A study protocol for a pilot randomized controlled trial to evaluate the effectiveness of a gene-based nutrition and lifestyle recommendation for weight management among adults: the MyGeneMyDiet(R) study. Front Nutr. 2023 Aug 22;10:1238234. doi: 10.3389/fnut.2023.1238234. eCollection 2023. | |
| 41654718 |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| Usual Standard of Care for Weight Management | Other | This group will receive the conventional and standard nutrition lifestyle recommendation for weight management |
|
| Physical activity level | Improvements in physical activity level | 24 weeks |
| Glycated haemoglobin (HbA1c) | Changes in HbA1c | 24 weeks |
| Blood lipid profile (TC, LDL-C, HDL-C, Triglycerides) | Changes in TC, LDL-C, HDL-C, Triglycerides | 24 weeks |
| Motivation for weight loss | Stages and motivation for weight loss | 24 weeks |
| Knowledge and perceptions | Knowledge and perceptions in nutrigenomics and genetic testing | 24 weeks |
| Derived |
| Nacis J, Labrador JP, Ronquillo DG, Rementilla JC, Rodriguez M, Madrid M, Frane R, Santos NL, Dablo AMF, Carrillo JJ, Fernandez MG, Fanio DJ, Martirez DA, Paller M, Monje HS, Cabigan RM, Bausas AA, Agra GM, Bunhiyan R, van Duijnhoven FJB, Gonzales GB. Effect of gene-based vs. standard weight-loss recommendations on anthropometry, lipid and glucose markers, and dietary intake: a randomized controlled trial (the MyGeneMyDiet(R) Study). Genes Nutr. 2026 Feb 7;21(1):4. doi: 10.1186/s12263-026-00794-z. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |