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In this prospective study we extracted acoustic parameters using PRAAT from patient's attempt to phonate during the clinical evaluation using a digital smart device. From these parameters we attempted (1) to define which of the PRAAT acoustic features best help to discriminate patients with dysphagia (2) to develop algorithms using sophisticated ML techniques that best classify those i) with dysphagia and those ii ) at high risk of respiratory complications due to poor cough force.
This study was prospective study, and patients who visited the department of rehabilitation medicine in a single university-affiliated tertiary hospital with dysphagic symptoms from September 2019 to March 2021 were included.Voice recording was performed at the enrollment with blinded assessment, where the participants first visited the rehabilitation department with chief complaints of dysphagia. The cough sounds were recorded with an iPad (Apple, Cupertino, CA, USA) through an embedded microphone.
From the acoustic files we extracted fourteen voice parameters that include the average value and standard deviation of the fundamental frequency (f0), harmonic-to-noise ratio (HNR), the jitter that refers to frequency instability, and the shimmer that represents the amplitude instability of the sound signal.
Machine learning algorithms and sophisticated deep neural network analysis will be performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dysphagia mild | Able to start oral feeding after assessment |
| |
| Dysphagia severe | Non oral feeding and high risk of aspiration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acoustic features (from signals obtained during phonation) | Other | Acoustic features will be obtained via phonation files. A voice recorder application provided by Apple was used, and the sampling frequency of the sound was 44,100 Hz. The digitized cough sound signals were band-pass-filtered between 20 to 16,000 Hz to use data from the whole frequency band gathered by the iPad. In each case, the smart device was positioned 20cm from the patient |
| Measure | Description | Time Frame |
|---|---|---|
| Functional Oral Intake Scale | Dysphagia severity as measured by the the Functional Oral Intake Scale obtained from standardized swallowing tests | during the intervention |
| Cough strength | Spirometry values : cough strength as measured by the spirometric values during voluntary cough | during the intervention |
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Inclusion Criteria:
- Inclusion criteria
Exclusion Criteria:
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First ever stroke patients referred for swallowing disorders
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| Name | Affiliation | Role |
|---|---|---|
| Sun Im, MD PhD | The Catholic University of Korea | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Rehabilitation Medicine Bucheon St Mary's Hospital, Catholic University of Korea, College of Medicine | Bucheon-si | Kyounggido | South Korea |
Data would be accessible only upon formal request to the formal PI
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| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D003680 | Deglutition Disorders |
| D055154 | Dysphonia |
| D020521 | Stroke |
| D011015 | Pneumonia, Aspiration |
| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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|
| D010608 | Pharyngeal Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D014832 | Voice Disorders |
| D007818 | Laryngeal Diseases |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D008171 | Lung Diseases |