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| Name | Class |
|---|---|
| Study Chair and Principal Investigator: Univ.-Prof. Dr. Alexander Zarbock | UNKNOWN |
| Principal Investigator: Dr. Andreas Margraf | UNKNOWN |
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Detection and determination of platelets in bronchoalveolar lavage fluid and blood in ARDS and non-ARDS-patients. Correlation with phenotype and inflammation parameters in blood and outcome parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pneumonia patients with ARDS | Patients in the perioperative/intensive care setting with pneumonia-induced ARDS requiring bronchoscopy. |
| |
| Ventilated patients without ARDS | Patients without ARDS on mechanical ventilation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bronchoscopy, blood sampling; testing. | Diagnostic Test | BAL and blood samples are measured by hematology analyzer, flow cytometry, western blot, RNAseq analysis and multiplex. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Detectability and changes in platelets in BAL and blood | 5-7 days | |
| Organ failure, survival. | 1 Year | |
| Systemic platelet and leukocyte numbers | 5-7 days | |
| Systemic platelet and leukocyte phenotypes. | 5-7 days | |
| Systemic cytokine profiles. | 5-7 days |
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Inclusion Criteria:
Exclusion Criteria:
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Perioperative patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carola Wempe, Dr | Contact | +4925147255 | wempe-c@anit.uni-muenster.de | |
| Andreas Margraf, Dr | Contact | +492518346843 | andreas.margraf@anit.uni-muenster.de |
| Name | Affiliation | Role |
|---|---|---|
| Alexander Zarbock, Univ.-Prof. Dr. | University Hospital Muenster | Study Chair |
| Andreas Margraf, Dr. | University Hospital Muenster | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Muenster | Recruiting | Münster | Germany |
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| ID | Term |
|---|---|
| D001791 | Blood Platelet Disorders |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| D001999 | Bronchoscopy |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004724 | Endoscopy |
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Bronchoalveolar lavage fluid, blood.
| D003949 | Diagnostic Techniques, Surgical |
| D019060 | Minimally Invasive Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D013510 | Pulmonary Surgical Procedures |
| D019616 | Thoracic Surgical Procedures |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D011677 | Punctures |
| D008919 | Investigative Techniques |