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Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.
We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HFNC group | Experimental |
|
|
| VM group | Active Comparator | - Keep FiO2 constant with VM and HFNC during the two trial |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high flow nasal cannula | Device | HFNC provides humidified, heated, oxygen-enriched air at constant concentration with a flow up to 60L/min through a nasal cannula. It washouts the anatomical dead space and decreases the work of breathing. |
| Measure | Description | Time Frame |
|---|---|---|
| Endurance time | Endurance time for 10 minute steping test | 10 minute |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory pattern | Respiratory pattern is calculated by the flow and time | 10 minute |
| Work of breathing | Work of breathing is calculated by the transdiaphragmatic pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shiying Fang, MD | Contact | +8602083062882 | fangshiying2019@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Rongchang Chen, PhD | The First Affiliated Hospital of Guangzhou Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shiying | Recruiting | Guangzhou | Guangdong | 510120 | China |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| Venturi mask | Device | VM is commonly used by COPD patients during exercise training. |
|
| 10 minute |
| Neural respiratory drive | Neural respiratory drive is calculated by diaphragm electromyogram | 10 minute |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |