Lung cancer is the leading cause of cancer related mortality. At present, surgical treatment is the main choice for early-stage lung cancer. Even after surgery, the 5-year recurrence rate is still as high as 18.4%-24%. Traditional Chinese medicine combined with thermal and cold ablation could be an alternative treatment. Small sample clinical cases verified that this therapy could be an efficacy and safe treatment in a short period. The primary aim of this trial is to evaluate the efficacy of traditional Chinese medicine combined with thermal and cold ablation for patients with stage I non-small cell lung cancer.

Inclusion Criteria:

• The patient can understand and voluntarily join the study, sign the informed consent form, and the compliance is good.
• Patients with lung nodule.
• Maximum diameter of lung nodule ≥8mm.
• The pathology of lung nodules biopsy was non-small cell lung cancer.
• I period according to the eighth edition of the TNM staging period.
• No mediastinal lymph node metastasis.
• Eastern Cooperative Oncology Group performance status of 0 to 1.
• No prior anticancer treatments including surgery, radiation,chemotherapy or local treatments.
• Sufficient organ functions.

Exclusion Criteria:

• Patients with previous use of various hormones, immunosuppression or autoimmune diseases.
• Women during pregnancy or breast-feeding.
• Patients with severe heart, lung, kidney disease or other systemic diseases
• Patients with severe hemorrhagic diseases.
• Patients with a history of drug abuse or mental illness.
• Other conditions that the investigator has determined are not suitable for participation in this study