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Efficacy of vaginal misoprostol 600 Mg versus 800 Mg in termination of the first trimester missed abortion were assist
In women with first trimetric-missed miscarriage, vaginal misoprostol in the achievement of successful miscarriage so our aim was to compare the effectiveness of vaginal misoprostol 600 Mg versus 800 Mg for medical treatment of the first trimester missed miscarriage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vaginal Misoprostol 600 mcg | Experimental | All patients will receive three doses of vaginal misoprostol every four hours. The first dose of misoprostol 600 mcg will be administrated at the hospital. Then the patient will be observed for 1 hour for any immediate adverse reaction Clear instructions about the method and timing of the second dose will be given upon sending home.
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| Vaginal Misoprostol 800 mcg | Active Comparator | All patients will receive three doses of vaginal misoprostol every four hours. The first dose of misoprostol 800 mcg will be administrated at the hospital. Then the patient will be observed for 1 hour for any immediate adverse reaction Clear instructions about the method and timing of the second dose will be given upon sending home.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vaginal Misoprostol 600 mcg | Drug | All patients will receive three doses of vaginal misoprostol every four hours. The first dose of misoprostol 600 mcg will be administrated at the hospital. Then the patient will be observed for 1 hour for any immediate adverse reaction Clear instructions about the method and timing of the second dose will be given upon sending home.
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| Measure | Description | Time Frame |
|---|---|---|
| Completeness of abortion | expulsion of Products of conception by visual inspection | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Successful medical abortion | cervical os is closed with endometrial thickness of less than 15 mm | 14 days |
| Bleeding pattern following treatment | This will be assessed by hemoglobin(g/dl) and haematocrit level after the treatment , if the patients required blood transfusion and number of units transfused and number of days of bleeding |
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Inclusion Criteria:
Exclusion Criteria:
pregnant women with missed abortion
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aswan University Hospital | Aswān | 81528 | Egypt |
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| ID | Term |
|---|---|
| D000022 | Abortion, Spontaneous |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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a double-blinded randomized trial
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a double-blinded randomized trial
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| Vaginal Misoprostol 800 mcg | Drug | All patients will receive three doses of vaginal misoprostol every four hours. The first dose of misoprostol 800 mcg will be administrated at the hospital. Then the patient will be observed for 1 hour for any immediate adverse reaction Clear instructions about the method and timing of second dose will be given upon sending home.
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| 7 days |
| Pain resulting from the procedure | this will be assessed by the doses of paracetamol given in mg | 7 days |
| Additional uterotonic used | additional misoprostol doses in mcg | 14 days |