A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035) | NCT05093933 | Trialant

A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035) | NCT05093933 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

History of chronic HF [New York Heart Association (NYHA) Class II to IV] on guideline-directed medical therapy for heart failure (GDMT) with no HF hospitalization within 6 months or outpatient IV diuretic use within 3 months before randomization.

Left ventricular ejection fraction (LVEF) of ≤40%, assessed within 12 months before randomization by any imaging method.

Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.

A female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP), or is a WOCBP and agrees to follow contraceptive guidance during the study intervention period and for at least 1 month after the last dose of study intervention.

Exclusion Criteria:

Has SBP <100 mm Hg or symptomatic hypotension.

Awaiting heart transplantation, is receiving continuous IV infusion of an inotrope, or has or anticipates receiving an implanted ventricular assist device.

Amyloidosis or sarcoidosis.

Primary valvular heart disease requiring surgical procedure or intervention or has undergone a valvular surgical procedure or intervention within 3 months before randomization.

Hypertrophic cardiomyopathy.

Acute myocarditis or Takotsubo cardiomyopathy.

History of heart transplant.

Tachycardia-induced cardiomyopathy and/or uncontrolled tachyarrhythmia.

Acute coronary syndrome, or undergone coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) within 3 months before randomization.

History of symptomatic carotid stenosis, transient ischemic attack (TIA), or stroke within 3 months before randomization.

Malignancy or other noncardiac condition limiting life expectancy to <3 years.

Requires continuous home oxygen for severe pulmonary disease.

Interstitial lung disease.

Discontinuation or dose modification of GDMT or vericiguat within 4 weeks before randomization.

Recent history (within the last year) of drug or alcohol abuse or dependence.

Advanced Cardiovascular - Alexander City ( Site 0038)

Alexander City, Alabama 35010, United States

University of Alabama at Birmingham - School of Medicine-Cardiology ( Site 0153)

Birmingham, Alabama 35294, United States

Heart Center Research, LLC ( Site 0156)

Huntsville, Alabama 35801, United States

Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075)

Gilbert, Arizona 85297, United States

Valley Clinical Trials, Inc. ( Site 0085)

Covina, California 91723, United States

VA West Los Angeles Medical Center-Cardiology ( Site 0149)

Los Angeles, California 90073, United States

Valley Clinical Trials Inc ( Site 0006)

Northridge, California 91325, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010)

Torrance, California 90502, United States

Blue Coast Research Center ( Site 0053)

Vista, California 92081, United States

Excel Medical Clinical Trials ( Site 0008)

Boca Raton, Florida 33434, United States

Universal Axon Clinical Research, LLC ( Site 0022)

Doral, Florida 33166, United States

Holy Cross Hospital ( Site 0100)

Fort Lauderdale, Florida 33308, United States

Indago Research and Health Center Inc ( Site 0011)

Hialeah, Florida 33012, United States

South Florida Research Solutions ( Site 0058)

Hollywood, Florida 33021, United States

University of Florida - Jacksonville ( Site 0169)

Jacksonville, Florida 32209, United States

East Coast Institute for Research, LLC ( Site 0047)

Jacksonville, Florida 32216, United States

Cardiovascular Research Center of South Florida ( Site 0074)

Miami, Florida 33173, United States

ProLive Medical Research ( Site 0032)

Miami, Florida 33175, United States

Peace River Cardiovascular Center ( Site 0088)

Port Charlotte, Florida 33952, United States

BAYCARE MEDICAL GROUP ( Site 0099)

Safety Harbor, Florida 34695, United States

East Coast Institute for Research - St. Augustine ( Site 0016)

Saint Augustine, Florida 32086, United States

Cardiovascular Center of Sarasota ( Site 0154)

Sarasota, Florida 34239, United States

Emory University School of Medicine ( Site 0123)

Atlanta, Georgia 30322, United States

IACT Health ( Site 0106)

Columbus, Georgia 31904, United States

NSC Research ( Site 0068)

Johns Creek, Georgia 30024, United States

Georgia Arrhythmia Consultants and Research Institute ( Site 0042)

Macon, Georgia 31201, United States

Cardiovascular Consultants of South Georgia, LLC ( Site 0137)

Thomasville, Georgia 31792, United States

Mount Sinai Hospital ( Site 0050)

Chicago, Illinois 60608, United States

Chicago Medical Research ( Site 0086)

Hazel Crest, Illinois 60429, United States

OSF Healthcare Cardiovascular Institute ( Site 0122)

Peoria, Illinois 61614, United States

Methodist Medical Center of Illinois ( Site 0098)

Peoria, Illinois 61636, United States

Franciscan Physician Network - Indiana Heart Physicians ( Site 0087)

Indianapolis, Indiana 46237, United States

The Heart Center of Lake County Research Institute-Research ( Site 0147)

Merrillville, Indiana 46410, United States

Cardiovascular Research of Northwest Indiana ( Site 0036)

Munster, Indiana 46321, United States

Reid Physician Associates ( Site 0054)

Richmond, Indiana 47374, United States

University of Iowa ( Site 0005)

Iowa City, Iowa 52242, United States

Alliance for Multispecialty Research, LLC ( Site 0143)

Wichita, Kansas 67207, United States

Norton Healthcare-Norton Heart Specialist ( Site 0062)

Louisville, Kentucky 40205, United States

Cambridge Medical Trials ( Site 0041)

Alexandria, Louisiana 71301, United States

Louisiana Heart Center - Hammond ( Site 0004)

Hammond, Louisiana 70403, United States

The Heart Clinic - Hammond ( Site 0155)

Hammond, Louisiana 70403, United States

Cardiovascular Institute of the South ( Site 0072)

Houma, Louisiana 70360, United States

Cardiovascular Institute of the South, 3 ( Site 0096)

Lafayette, Louisiana 70503, United States

IMA Clinical Research ( Site 0112)

Monroe, Louisiana 71201, United States

Cardiovascular Institute of the South ( Site 0081)

Opelousas, Louisiana 70570, United States

Maryland Cardiovascular Specialists ( Site 0056)

Baltimore, Maryland 21229, United States

Capitol Cardiology Associates - Lanham Office-Maryland Research Centers ( Site 0167)

Lanham, Maryland 20706, United States

Ascension Providence Hospital ( Site 0094)

Southfield, Michigan 48075, United States

Phillips Medical Services ( Site 0070)

Jackson, Mississippi 39209, United States

The University of Mississippi Medical Center-Cardiovascular ( Site 0073)

Jackson, Mississippi 39216, United States

University of Missouri Hospital ( Site 0163)

Columbia, Missouri 65212, United States

Washington University-Department of Medicine ( Site 0044)

St Louis, Missouri 63110, United States

St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029)

St Louis, Missouri 63136, United States

Logan Health Research ( Site 0017)

Kalispell, Montana 59901, United States

Renown Regional Medical Center-Renown Institute for Heart and Vascular Health ( Site 0168)

Reno, Nevada 89502, United States

Amici Clinical Research LLC-Research ( Site 0037)

Raritan, New Jersey 08869, United States

The Valley Hospital ( Site 0035)

Ridgewood, New Jersey 07450, United States

Cardiovascular Associates of the Delaware Valley ( Site 0097)

Washington Township, New Jersey 08080, United States

Erie County Medical Center ( Site 0160)

Buffalo, New York 14215, United States

New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127)

Cortlandt Manor, New York 10567, United States

Icahn School of Medicine at Mount Sinai ( Site 0161)

New York, New York 10029-5674, United States

CHEAR Center LLC ( Site 0009)

The Bronx, New York 10455, United States

Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134)

Lumberton, North Carolina 28358, United States

Accellacare - Wilmington ( Site 0090)

Wilmington, North Carolina 28401, United States

Aultman Hospital-Cardiology Clinical Trials ( Site 0064)

Canton, Ohio 44710, United States

University of Cincinnati Medical Center-Cardiology ( Site 0071)

Cincinnati, Ohio 45219, United States

ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061)

Toledo, Ohio 43606, United States

Doylestown Hospital-Cardiology ( Site 0030)

Doylestown, Pennsylvania 18901, United States

Accellacare - Charleston ( Site 0141)

Charleston, South Carolina 29464, United States

Apex Research Foundation ( Site 0001)

Jackson, Tennessee 38301, United States

Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060)

Nashville, Tennessee 37232, United States

Dallas VA Medical Center ( Site 0084)

Dallas, Texas 75216, United States

Southwest Family Medicine Associates ( Site 0131)

Dallas, Texas 75235, United States

Medresearch Inc ( Site 0043)

El Paso, Texas 79935, United States

West Houston Area Clinical Trial Consultants ( Site 0014)

Houston, Texas 77094, United States

South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024)

Kerrville, Texas 78028, United States

South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020)

San Antonio, Texas 78201, United States

Tyler Cardiovascular Consultants ( Site 0039)

Tyler, Texas 75701, United States

INOVA Fairfax Medical Campus ( Site 0136)

Falls Church, Virginia 22042, United States

Carient Heart & Vascular - Manassas ( Site 0059)

Manassas, Virginia 20109, United States

Sentara Norfolk General Hospital ( Site 0114)

Norfolk, Virginia 23507, United States

Dominion Medical Associates, Inc. ( Site 0089)

Richmond, Virginia 23219, United States

Pulse Heart Institute - Puyallup ( Site 0119)

Puyallup, Washington 98372, United States

MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102)

Spokane, Washington 99204, United States

CEDIC ( Site 4363)

CABA, Buenos Aires C1060ABN, Argentina

Centro de Investigaciones Metabólicas (CINME)-Cardiology ( Site 4352)

Ciudad Autónoma de Buenos Aires, Buenos Aires C1027AAP, Argentina

DIM Clínica Privada ( Site 4359)

Ramos Mejía, Buenos Aires B1704ETD, Argentina

Instituto de Investigaciones Clinicas Zarate ( Site 4360)

Zárate, Buenos Aires B2800DGH, Argentina

Centro Médico Viamonte-Clinical Research ( Site 4361)

Buenos Aires, Buenos Aires F.D. C1120AAC, Argentina

Fundacion Estudios Clinicos ( Site 4356)

Rosario, Santa Fe Province S2000DEJ, Argentina

Centro de Investigaciones Clinicas del Litoral ( Site 4354)

Santa Fe, 3000, Argentina

Royal Brisbane and Women's Hospital-Cardiology Research ( Site 0453)

Brisbane, Queensland 4029, Australia

The Prince Charles Hospital-Cardiology Research Centre ( Site 0451)

Brisbane, Queensland 4032, Australia

Core Research Group ( Site 0452)

Brisbane, Queensland 4064, Australia

Royal Adelaide Hospital-Cardiology ( Site 0456)

Adelaide, South Australia 5000, Australia

Flinders Medical Centre-Cardiology Research ( Site 0455)

Bedford Park, South Australia 5042, Australia

St. John of God Subiaco Hospital ( Site 0457)

Subiaco, Western Australia 6008, Australia

Imed19-privat ( Site 0353)

Vienna, State of Vienna A-1190, Austria

Medizinische Universität Graz-Department of Cardiology ( Site 0351)

Graz, Styria 8036, Austria

Krankenhaus St. Josef Braunau ( Site 0354)

Braunau am Inn, Upper Austria 5280, Austria

Uniklinikum Salzburg-Universitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensiv

Salzburg, 5020, Austria

Klinik Floridsdorf-Karl Landsteiner Institute for Cardiovascular and Critical Care Research c/o Dep

Vienna, 1210, Austria

Hospital de Messejana Dr Carlos Alberto Studart Gomes ( Site 0560)

Fortaleza, Ceará 60864-190, Brazil

Universidade Federal de Goias-Serviço de Cardiologia ( Site 0553)

Goiânia, Goiás 74605-020, Brazil

PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR ( Site 0555)

Curitiba, Paraná, Brazil

Hospital Mae de Deus ( Site 0564)

Porto Alegre, Rio Grande do Sul 90880-480, Brazil

Centro de Pesquisa Clinica do Coracao ( Site 0561)

Acaraju, Sergipe 49055-530, Brazil

Instituto de Pesquisa clinica de Campinas ( Site 0551)

Campinas, São Paulo 13060-080, Brazil

CAPED Centro Avancado Pesquisa e Diagnostica ( Site 0552)

Ribeirão Preto, São Paulo 14026-900, Brazil

Hospital de Clínicas de Ribeirão Preto ( Site 0559)

Ribeirão Preto, São Paulo 14048900, Brazil

Hospital Pro-Cardiaco ( Site 0556)

Rio de Janeiro, 22280-003, Brazil

Incor - Instituto do Coracao ( Site 0557)

São Paulo, 05403-900, Brazil

Heritage Medical Research Clinic ( Site 0679)

Calgary, Alberta T2N 4Z6, Canada

University Of Alberta Hospital ( Site 0669)

Edmonton, Alberta T6G 2B7, Canada

Victoria Heart Institute Foundation ( Site 0680)

Victoria, British Columbia V8R 1B2, Canada

St. Boniface General Hospital ( Site 0667)

Winnipeg, Manitoba R2H 2A6, Canada

G A Research Associates ( Site 0652)

Moncton, New Brunswick E1G 1A7, Canada

NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664)

Halifax, Nova Scotia B3H 3A7, Canada

Cambridge Cardiac Care Centre ( Site 0658)

Cambridge, Ontario N1R 6V6, Canada

PACE Cardiology ( Site 0675)

Newmarket, Ontario L3Y 2P6, Canada

North York Diagnostic and Cardiac Centre ( Site 0682)

North York, Ontario M6B 3H7, Canada

Oakville Cardiovascular Research LP ( Site 0657)

Oakville, Ontario L6K 3W7, Canada

Private Practice - Dr. James Cha ( Site 0655)

Oshawa, Ontario L1J 2K1, Canada

Kawartha Cardiology Clinical Trials ( Site 0654)

Peterborough, Ontario K9J 0B2, Canada

Corcare-Corcare Cardiovascular Research ( Site 0660)

Toronto, Ontario M1B 5N1, Canada

Medicus MFC Research Clinic ( Site 0676)

Toronto, Ontario M4P 1E4, Canada

Hôpital de la Cité-de-la-Santé ( Site 0673)

Laval, Quebec H7M 3L9, Canada

Institut de Cardiologie de Montreal ( Site 0661)

Montreal, Quebec H1T 1C8, Canada

Montreal General Hospital ( Site 0653)

Montreal, Quebec H3G 1A4, Canada

Unité de Recherche Clinique du CISSS des Laurentides ( Site 0668)

Saint-Jérôme, Quebec J7Z 2V4, Canada

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer

Sherbrooke, Quebec J1H 5N4, Canada

Hopital Pierre-Le Gardeur ( Site 0674)

Terrebonne, Quebec J6V 2H2, Canada

Diex Recherche Trois-Rivieres ( Site 0677)

Trois-Rivières, Quebec G9A 4P3, Canada

Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0752)

Temuco, Araucania 4780000, Chile

IC La Serena Research ( Site 0769)

La Serena, Coquimbo Region 1720430, Chile

Clinica Alemana Osorno ( Site 0768)

Osorno, Los Lagos Region 5311089, Chile

Clinical Research Chile SpA ( Site 0761)

Valdivia, Los Ríos Region 5110683, Chile

Enroll SpA ( Site 0755)

Santiago, Region M. de Santiago 7500587, Chile

Clinica Dermacross ( Site 0760)

Santiago, Region M. de Santiago 7640881, Chile

Espacio Eme ( Site 0762)

Santiago, Region M. de Santiago 7770086, Chile

Hospital y CRS El Pino ( Site 0763)

Santiago, Region M. de Santiago 8053095, Chile

Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0754)

Santiago, Region M. de Santiago 8330111, Chile

Clínica Ensenada ( Site 0753)

Santiago, Region M. de Santiago 8380465, Chile

Cardio Sur ( Site 0756)

Santiago, Region M. de Santiago 8910259, Chile

ONCOCENTRO APYS ( Site 0770)

Viña del Mar, Valparaiso 2520598, Chile

Anhui Provincil Hospital South District ( Site 0920)

Hefei, Anhui 230036, China

Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 0856)

Beijing, Beijing Municipality 100029, China

Aero Space Center Hospital ( Site 0918)

Beijing, Beijing Municipality 100049, China

Beijing Friendship Hospital-Cardology ( Site 0865)

Beijing, Beijing Municipality 100050, China

Beijing Tsinghua Changgung Hospital ( Site 0911)

Beijing, Beijing Municipality 102218, China

The Second Affiliated Hospital Chongqing Medical University-Department of Cardiology ( Site 0908)

Chongqing, Chongqing Municipality 400010, China

Chongqing Three Gorges Central Hospital ( Site 0913)

Wanzhou, Chongqing Municipality 404199, China

Lanzhou university second hospital-Lanzhou university second hospital ( Site 0863)

Lanzhou, Gansu 730030, China

The First People's Hospital of Foshan ( Site 0898)

Foshan, Guangdong 528041, China

Guangdong Provincial People's Hospital-Cardiology ( Site 0852)

Guangzhou, Guangdong 510080, China

Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Cardiology ( Site 0868)

Guangzhou, Guangdong 510120, China

The First Affiliated Hospital of Jinan University ( Site 0897)

Guangzhou, Guangdong 510630, China

The University of Hong Kong - Shenzhen Hospital-Cardiovascular department ( Site 0895)

Shenzhen, Guangdong 518053, China

Hainan General Hospital ( Site 0894)

Haikou, Hainan 570311, China

The First Hospital of Harbin Medical University-Cardiology ( Site 0903)

Harbin, Heilongjiang 150001, China

Wuhan Union Hospital ( Site 0919)

Wuhan, Hubei 430022, China

Changsha Central Hospital ( Site 0854)

Changsha, Hunan 410004, China

Hunan Provincial People's Hospital ( Site 0857)

Changsha, Hunan 410005, China

Xiangya Hospital Central South University-Cardiological Department ( Site 0899)

Changsha, Hunan 410008, China

The Third Xiangya Hospital of Central South University-Cardiology ( Site 0860)

Changsha, Hunan 410013, China

BAO TOU CENTRAL HOSPITAL ( Site 0866)

Baotou, Inner Mongolia 014040, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Cardiolggy

Nanjing, Jiangsu 210000, China

The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 0900)

Nanjing, Jiangsu 210011, China

Wuxi No.2 People's Hospital-Cardiology Department ( Site 0877)

Wuxi, Jiangsu 214002, China

Wuxi People's Hospital-Cardiovascular Department ( Site 0870)

Wuxi, Jiangsu 214023, China

The Affiliated Hospital of Xuzhou Medical College ( Site 0910)

Xuzhou, Jiangsu 221006, China

Northern Jiangsu People's Hospital ( Site 0861)

Yangzhou, Jiangsu 225001, China

Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 0917)

Zhenjiang, Jiangsu 212001, China

The Second Affiliated Hospital of Nanchang University-Cardiology ( Site 0912)

Nanchang, Jiangxi 330006, China

China-Japan Union Hospital-department of cardiology ( Site 0916)

Changchun, Jilin 130033, China

Siping Central People's Hospital-Cardiovascular Department ( Site 0915)

Siping, Jilin 136000, China

The People's Hospital of Liaoning Province ( Site 0859)

Shenyang, Liaoning 110016, China

The First Affiliated Hospital of Xian Jiaotong University ward1 depattment of medical oncology ( Sit

Xi'an, Shaanxi 710061, China

Shaanxi provincial people's hospital ( Site 0853)

Xi'an, Shaanxi 710068, China

Shanghai Jiaotong University School of Medicine Ruijin Hospital-Cardiology Department ( Site 0855)

Shanghai, Shanghai Municipality 200001, China

Zhongshan Hospital,Fudan University-Cardiology ( Site 0851)

Shanghai, Shanghai Municipality 200032, China

Shanghai Tongji Hospital-Cardiovascular Department ( Site 0905)

Shanghai, Shanghai Municipality 200065, China

Shanghai Yangpu District Central Hospital-Cardiology ( Site 0876)

Shanghai, Shanghai Municipality 200090, China

Shanghai Xuhui Central Hospital-Cardiovascular Department ( Site 0872)

Shanghai, Shanghai Municipality, China

West China Hospital Sichuan University ( Site 0904)

Chengdu, Sichuan 610041, China

The Second Hospital of Tianjin Medical University-Endocrinology ( Site 0902)

Tianjin, Tianjin Municipality 300211, China

Tianjin Chest Hospital-Cardiology ( Site 0901)

Tianjin, Tianjin Municipality 300222, China

Tianjin People' s Hospital ( Site 0867)

Tianjin, Tianjin Municipality, China

The First Affiliated Hospital, Zhejiang University ( Site 0907)

Hangzhou, Zhejiang 310003, China

The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0909)

Hangzhou, Zhejiang 310052, China

Zhejiang Provincial People's Hospital ( Site 0914)

Hangzhou, Zhejiang 311599, China

People's Hospital of Lishui City-department of cardiovascular ( Site 0862)

Lishui, Zhejiang 323000, China

The First Affiliated Hospital of Wenzhou Medical University-Vasculocardiology Department ( Site 0874

Wenzhou, Zhejiang 325000, China

Fundación Centro de Investigación Clínica CIC ( Site 0955)

Medellín, Antioquia 050021, Colombia

Centro Cardiovascular Colombiano Clínica Santa María ( Site 0951)

Medellín, Antioquia 050034, Colombia

Rodrigo Botero S.A.S ( Site 0953)

Medellín, Antioquia 50030, Colombia

Clinica de la Costa S.A.S. ( Site 0954)

Barranquilla, Atlántico 080020, Colombia

Corazon IPS ( Site 0964)

Barranquilla, Atlántico 080020, Colombia

IPS Centro Científico Asistencial S.A.S ( Site 0952)

Barranquilla, Atlántico 080020, Colombia

IPS Médicos Internistas de Caldas ( Site 0959)

Manizales, Caldas Department 170004, Colombia

Instituto Del Corazón De Bucaramanga ( Site 0960)

Bucaramanga, Santander Department 680002, Colombia

Fundación Cardiovascular de Colombia ( Site 0961)

Piedecuesta, Santander Department 681017, Colombia

Fundacion Valle del Lili- CIC-Internal Medicine ( Site 0962)

Cali, Valle del Cauca Department 760032, Colombia

Centro de Investigaciones Clinicas SAS ( Site 0957)

Cali, Valle del Cauca Department 760036, Colombia

Clínica Imbanaco S.A.S ( Site 0963)

Cali, Valle del Cauca Department, Colombia

Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 1058)

Brno, Brno-mesto 625 00, Czechia

Vojenská Nemocnice Brno-Internal department ( Site 1055)

Brno, Brno-mesto 636 00, Czechia

Nemocnice Slany-Interna - kardiologicka ambulance ( Site 1063)

Slaný, Central Bohemia 274 01, Czechia

Klinika Dr. Pirka ( Site 1065)

Mladá Boleslav, Mlada Boleslav 293 01, Czechia

Institut Klinicke a Experimentalni Mediciny-Klinika kardiologie ( Site 1052)

Prague, Praha 4 14021, Czechia

Ustredni vojenska nemocnice-Oddeleni kardiologie ( Site 1054)

Prague, Praha 6 169 02, Czechia

MUDr. Libor Nechvatal s.r.o. , Kardiologie ( Site 1057)

Brno, South Moravian 602 00, Czechia

Fakultni Nemocnice u sv. Anny v Brne-I. interni kardioangiologicka klinika ( Site 1066)

Brno, South Moravian 60200, Czechia

KardioBusak s.r.o. ( Site 1051)

Louny, 44001, Czechia

Vseobecna fakultni nemocnice v Praze-Centrum srdečního selhání ( Site 1059)

Prague, 12808, Czechia

KIGE ( Site 1060)

Znojmo, 66902, Czechia

Rigshospitalet-Cardiology ( Site 1161)

Copenhagen, Capital Region 2100, Denmark

Amager Hospital ( Site 1163)

Copenhagen, Capital Region 2300, Denmark

Herlev and Gentofte Hospital-Department of Cardiology ( Site 1158)

Hellerup, Capital Region 2900, Denmark

Nordsjællands Hospital - Hillerød ( Site 1159)

Hillerød, Capital Region 3400, Denmark

Hvidovre Hospital-259 ( Site 1151)

Hvidovre, Capital Region 2650, Denmark

Aarhus Universitetshospital, Skejby ( Site 1160)

Aarhus, Central Jutland 8200, Denmark

Regionshospitalet Viborg ( Site 1166)

Viborg, Central Jutland 8800, Denmark

Sygehus Vendsyssel Hjoerring ( Site 1164)

Hjørring, North Denmark 9800, Denmark

Holbæk Sygehus-Cardiology ( Site 1152)

Holbæk, Region Sjælland 4300, Denmark

Roskilde Sygehus ( Site 1162)

Roskilde, Region Sjælland 4000, Denmark

Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1153)

Slagelse, Region Sjælland 4200, Denmark

Sydvestjysk Sygehus Esbjerg-Hjertemedicinsk Projekt ( Site 1154)

Esbjerg, Region Syddanmark 6700, Denmark

Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1156)

Svendborg, Region Syddanmark 5700, Denmark

Centre Hospitalier Universitaire de Nice - Hopital Pasteur-Service cardiologie ( Site 1353)

Nice, Alpes-Maritimes 06000, France

CHU Bordeaux Haut-Leveque ( Site 1362)

Pessac, Aquitaine 33600, France

Centre Hospitalier Louis Pasteur ( Site 1360)

Le Coudray, Eure-et-Loir 28630, France

CHU Rangueil-Cardiology ( Site 1351)

Toulouse, Haute-Garonne 31059, France

CHU Charles Nicolle ( Site 1354)

Rouen, Haute-Normandie 76031, France

Centre Hospitalier Régional Universitaire de Nancy - Hôpitau-Centre Investigation Clinique Plurithé

Vandœuvre-lès-Nancy, Lorraine 54511, France

Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 1356)

Le Kremlin-Bicêtre, Paris 94270, France

Centre Hospitalier intercommunal de Toulon La Seyne sur Mer ( Site 1352)

Toulon, Provence-Alpes-Côte d'Azur Region 83100, France

Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1364)

Lyon, Rhone 69677, France

CHD Vendee ( Site 1361)

La Roche-sur-Yon, Vendee 85000, France

Pitie Salpetriere University Hospital ( Site 1363)

Paris, Île-de-France Region 75013, France

Universitaetsklinikum Heidelberg-Klinik für Kardiologie, Angiologie und Pneumologie ( Site 1475)

Heidelberg, Baden-Wurttemberg 69120, Germany

Klinikum Coburg ( Site 1464)

Coburg, Bavaria, Germany

Kardiologische Gemeinschaftspraxis ( Site 1460)

Nuremberg, Bavaria 90402, Germany

Universitaetsklinikum Wuerzburg ( Site 1458)

Würzburg, Bavaria 97080, Germany

ClinPhenomics CVC GmbH ( Site 1457)

Frankfurt am Main, Hesse 60596, Germany

Klinikum Frankfurt Höchst ( Site 1463)

Frankfurt am Main, Hesse 65929, Germany

Asklepios Klinik Langen ( Site 1473)

Langen, Hesse 63225, Germany

Medizinische Hochschule Hannover ( Site 1476)

Hanover, Lower Saxony 30625, Germany

Universitätsmedizin Greifswald ( Site 1470)

Greifswald, Mecklenburg-Vorpommern 17475, Germany

St. Vinzenz-Hospital-Cardiology ( Site 1455)

Cologne, North Rhine-Westphalia 50733, Germany

Klinikum Leverkusen ( Site 1453)

Leverkusen, North Rhine-Westphalia 51375, Germany

Kliniken Maria Hilf-Klinik für Kardiologie ( Site 1454)

Mönchengladbach, North Rhine-Westphalia 41063, Germany

Gemeinschaftspraxis Dr. Fabian Krämer, Dr. Ulrich Overhoff ( Site 1459)

Siegen, North Rhine-Westphalia 57072, Germany

Klinikum Ludwigshafen ( Site 1456)

Ludwigshafen am Rhein, Rhineland-Palatinate 67063, Germany

Marienhaus Klinikum St. Elisabeth Neuwied ( Site 1452)

Neuwied, Rhineland-Palatinate 56564, Germany

Staedtisches Klinikum Dresden-2. Medizinische Klinik ( Site 1468)

Dresden, Saxony 01067, Germany

Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien ( Site 1477)

Dresden, Saxony 01277, Germany

Herzzentrum Dresden GmbH Universitätsklinik ( Site 1469)

Dresden, Saxony 01307, Germany

Katholisches Krankenhaus St. Johann Nepomuk ( Site 1462)

Erfurt, Thuringia 99097, Germany

Praxis Rankestrasse ( Site 1461)

Berlin, 10789, Germany

Cardiologicum Hamburg ( Site 1467)

Hamburg, 22041, Germany

General Hospital of Athens Hippokratio ( Site 1552)

Athens, Attica 115 27, Greece

Alexandra Hospital-HEART FAILURE AND CARDIO-ONCOLOGY UNIT ( Site 1559)

Athens, Attica 115 28, Greece

General Hospital of Athens "G. Gennimatas"-General Hospital of Athens "G.Gennimatas" ( Site 1561)

Athens, Attica 11527, Greece

Konstantopoulio General Hospital-Cardiology Clinic ( Site 1553)

Athens, Attica 142 33, Greece

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1556)

Chaïdári, Attica 124 62, Greece

Hygeia Hospital-6th cardiology clinic ( Site 1560)

Marousi, Attica 151 23, Greece

University Hospital of Alexandroupolis-First Department of Internal Medicine ( Site 1551)

Alexanroupolis, Evros 681 00, Greece

University General Hospital of Larissa ( Site 1555)

Larissa, Thessaly 411 10, Greece

University Hospital of Ioannina-2nd Department of Cardiology ( Site 1554)

Ioannina, West Greece 455 00, Greece

AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 1558)

Thessaloniki, 546 36, Greece

European Interbalkan Medical Center-2nd Department of Cardiology ( Site 1557)

Thessaloniki, 57001, Greece

Unidad De Diagnostico Cardiologico ( Site 1652)

Guatemala City, 01001, Guatemala

Clinica Medica ( Site 1651)

Guatemala City, 01010, Guatemala

Unidad De Diagnostico Cardiologico ( Site 1654)

Guatemala City, Guatemala

Grantham Hospital ( Site 1753)

Aberdeen, 999077, Hong Kong

Queen Mary Hospital-Medicine - Cardiology ( Site 1752)

Hksar, Hong Kong

Princess Margaret Hospital ( Site 1755)

Hong Kong, Hong Kong

Prince of Wales Hospital ( Site 1751)

Shatin, NT, Hong Kong

CoroMed ( Site 1867)

Pécs, Baranya 7623, Hungary

Pécsi Tudományegyetem Klinikai Központ ( Site 1865)

Pécs, Baranya 7624, Hungary

Private Practice - Dr. Lakatos Ferenc ( Site 1854)

Békéscsaba, Bekes County 5600, Hungary

Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Cardiology ( Site 1878)

Gyula, Bekes County 5700, Hungary

Bacs-Kiskun Megyei Korhaz-I. Belgyógyászat - Kardiológia ( Site 1873)

Kecskemét, Bács-Kiskun county 6000, Hungary

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1874)

Szeged, Csongrád megye 6725, Hungary

TaNa Med ( Site 1866)

Mosonmagyaróvár, Győr-Moson-Sopron 9200, Hungary

Flor Ferenc Hospital of Pest County-5th Department of Internal Medicine ( Site 1852)

Kistarcsa, Pest County 2143, Hungary

CMed Rehabilitacios es Diagnosztikai Kozpont ( Site 1877)

Székesfehérvár, Szekesfehervar 8000, Hungary

Tolna Megyei Balassa János Kórház ( Site 1868)

Szekszárd, Szekszard 7100, Hungary

DRC Gyógyszervizsgáló Központ ( Site 1869)

Balatonfüred, Veszprém megye 8230, Hungary

Szent Rókus Kórház ( Site 1858)

Budapest, 1085, Hungary

Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1851)

Budapest, 1096, Hungary

Semmelweis University-Városmajori Szív- és Érgyógyászati Klinika ( Site 1855)

Budapest, 1122, Hungary

Óbudai Egészségügyi Centrum ( Site 1861)

Budapest, 1932, Hungary

Medifarma 98 Kft-Outpatient Clinic ( Site 1859)

Nyíregyháza, 4400, Hungary

OEC Clinical Research - Zalaegerszeg ( Site 1864)

Zalaegerszeg, 8900, Hungary

St. Michael's Hospital ( Site 1955)

Dún Laoghaire, Dublin A96 D628, Ireland

St. James's Hospital-Cardiology ( Site 1951)

Dublin, D08 E9P6, Ireland

Assuta Ashdod Medical Center-Cardiology ( Site 2063)

Ashdod, 7747629, Israel

Hillel Yaffe Medical Center-Heart Institute ( Site 2058)

Hadera, 3810101, Israel

Rambam Health Care Campus-Cardiology ( Site 2053)

Haifa, 3109601, Israel

Shaare Zedek Medical Center-Cardiology ( Site 2055)

Jerusalem, 9013102, Israel

Hadassah Medical Center-Heart Institute ( Site 2062)

Jerusalem, 9112001, Israel

Galilee Medical Center-Cardiology ( Site 2051)

Nahariya, 2210001, Israel

Rabin Medical Center-Cardiology - CHF ( Site 2052)

Petah Tikva, 49100, Israel

Sheba Medical Center-Leviev Heart Center ( Site 2064)

Ramat Gan, 5262100, Israel

Kaplan Medical Center-Heart Institution ( Site 2054)

Rehovot, 7610001, Israel

Yitzhak Shamir Medical Center-Cardiology ( Site 2060)

Ẕerifin, 609300, Israel

Azienda Ospedaliero Universitaria S.Anna ( Site 2152)

Cona, Emilia-Romagna 44124, Italy

Cattinara Hospital-Cardiovascular Department ( Site 2162)

Trieste, Friuli Venezia Giulia 34149, Italy

Policlinico Umberto I ( Site 2166)

Rome, Lazio 00161, Italy

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-U.O.C. Cardiologia ( Site 2161)

Milan, Lombardy 20122, Italy

Centro Cardiologico Monzino-Heart Failure Unit ( Site 2153)

Milan, Lombardy 20138, Italy

ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 2159)

Milan, Milano 20162, Italy

IRCCS San Raffaele Pisana-riabilitazione cardiologica ( Site 2156)

Rome, Roma 00163, Italy

ospedale le scotte ( Site 2163)

Siena, Tuscany 53100, Italy

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 2151)

Bergamo, 24127, Italy

IRCCS - AOU di Bologna-Dept. of Medical and Surgical sciences ( Site 2158)

Bologna, 40138, Italy

Azienda Ospedaliera Spedali Civili di Brescia-Cardiology- Day Hospital ( Site 2154)

Brescia, 25123, Italy

Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 2157)

Pavia, 27100, Italy

University of Perugia ( Site 2164)

Perugia, 06132, Italy

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 2165)

Torino, 10126, Italy

Hospital Sultanah Bahiyah-Department of Cardiology ( Site 2355)

Alor Star, Kedah 05460, Malaysia

Hospital Universiti Sains Malaysia-Medical Department ( Site 2357)

Kubang Kerian, Kelantan 16150, Malaysia

University Malaya Medical Centre ( Site 2351)

Lembah Pantai, Kuala Lumpur 59100, Malaysia

Hospital Tengku Ampuan Afzan ( Site 2353)

Kuantan, Pahang 25100, Malaysia

Hospital Queen Elizabeth II ( Site 2359)

Kota Kinabalu, Sabah 88300, Malaysia

Sarawak Heart Centre ( Site 2352)

Kota Samarahan, Sarawak 94300, Malaysia

UiTM Sungai Buloh Campus ( Site 2354)

Sungai Buloh, Selangor 47000, Malaysia

Hospital Sultanah Nur Zahirah-Jabatan Perubatan ( Site 2360)

Kuala Terengganu, Terengganu 20400, Malaysia

Medivest Centro de Investigación Integral ( Site 2460)

Chihuahua City, Chihuahua 31203, Mexico

CIMAB SA de CV ( Site 2456)

Torreón, Coahuila 27000, Mexico

Centro de Investigacion Cardiovascular y Metabólica ( Site 2465)

Tijuana, Estado de Baja California 22500, Mexico

Hospital General de Acapulco ( Site 2469)

Acapulco de Juárez, Guerrero 39901, Mexico

Grupo Ollin Care ( Site 2476)

Pachuca, Hidalgo 42000, Mexico

Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente ( Site 2466)

Guadalajara, Jalisco 44150, Mexico

Cardiocent de Guadalajara S.C. ( Site 2464)

Guadalajara, Jalisco 44160, Mexico

Instituto Jalisciense de Metabolismo SC ( Site 2467)

Guadalajara, Jalisco 44670, Mexico

HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA ( Site 2478)

Mexico City, Mexico City 06720, Mexico

Centro de Imagen y Tecnología en Intervención Cardiovascular ( Site 2477)

Mexico City, Mexico City 10400, Mexico

Instituto Nacional de Cardiologia Ignacio Chavez ( Site 2454)

Mexico City, Mexico City 14080, Mexico

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 2474)

Mexico City, Mexico City 14080, Mexico

Unidad biomedica avanzada monterrey ( Site 2462)

Monterrey, Nuevo León 64460, Mexico

Unidad Médica para la Salud Integral ( Site 2472)

San Nicolás de los Garza, Nuevo León 66465, Mexico

Centro de Atención e Investigación Cardiovascular del Potosí ( Site 2453)

San Luis Potosí City, San Luis Potosí 78200, Mexico

Centro de Estudios de Alta Especialidad de Sinaloa ( Site 2463)

Mazatlán, Sinaloa 82113, Mexico

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2468)

Ciudad Madero, Tamaulipas 89440, Mexico

Consultorio de Medicina Especilizada del Sector Privado ( Site 2455)

Xalapa, Veracruz 91193, Mexico

Hospital Angeles Xalapa ( Site 2451)

Xalapa, Veracruz 91193, Mexico

Medical Care and Research SA de CV ( Site 2461)

Mérida, Yucatán 97070, Mexico

Fundación Cardiovascular de Aguascalientes A.C. ( Site 2473)

Aguascalientes, 20230, Mexico

Oaxaca Site Management Organization ( Site 2459)

Oaxaca City, 68000, Mexico

Centro de Investigacion Clinica de Oaxaca ( Site 2457)

Oaxaca City, 68020, Mexico

Christchurch Heart Institute ( Site 2651)

Christchurch, Canterbury 8011, New Zealand

Dunedin Hospital-Cardiology Department ( Site 2653)

Dunedin, Otago 9016, New Zealand

Waikato Hospital-Cardiology Clinical Trials Unit ( Site 2654)

Hamilton, Waikato Region 3204, New Zealand

Hutt Valley District Health board HVDHB-Cardiology Research Unit ( Site 2652)

Lower Hutt, Wellington Region 5010, New Zealand

North Shore Hospital-Cardiology Research ( Site 2656)

Auckland, 0622, New Zealand

Auckland City Hospital ( Site 2659)

Auckland, 1023, New Zealand

Middlemore Clinical Trials ( Site 2658)

Auckland, 2025, New Zealand

Centro de investigacion Clínica Trujillo-Medical specialties ( Site 2860)

Trujillo, La Libertad 13001, Peru

Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2855)

Jesús María, Lima 15072, Peru

Hospital Alberto Sabogal Sologuren ( Site 2851)

Bellavista, Qallaw 07011, Peru

Clínica Vesalio-Cardiology ( Site 2854)

Lima, 15036, Peru

Clínica Javier Prado ( Site 2853)

Lima, 15046, Peru

Clínica El Golf-Cardiologia ( Site 2857)

Lima, 15076, Peru

Clínica Providencia ( Site 2856)

Lima, 15088, Peru

Hospital Cayetano Heredia-Servicio de cardiologia ( Site 2852)

Lima, Lima 31, Peru

Clínica Belén ( Site 2858)

Piura, 20000, Peru

NZOZ Centrum Medyczne KERmed ( Site 3066)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship 85-231, Poland

Praktyka Lekarska Lidia Pawlowicz ( Site 3053)

Torun, Kuyavian-Pomeranian Voivodeship 87-100, Poland

Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu-Oddz.Klin.Kardiologii i Int.T.Kard. ( Si

Torun, Kuyavian-Pomeranian Voivodeship 87-100, Poland

Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 3062)

Chrzanów, Lesser Poland Voivodeship 32-500, Poland

Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. ( Site 3061)

Krakow, Lesser Poland Voivodeship 31-216, Poland

Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site

Tarnów, Lesser Poland Voivodeship 33-100, Poland

Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 3070)

Legnica, Lower Silesian Voivodeship 59-220, Poland

Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia ( Site 3057)

Wrocaw, Lower Silesian Voivodeship 50-556, Poland

NZOZ Twoja Przychodnia ( Site 3051)

Lublin, Lublin Voivodeship 20-857, Poland

SP ZOZ w Puławach- Oddział Kardiologii ( Site 3071)

Puławy, Lublin Voivodeship 24-100, Poland

ETG Warszawa ( Site 3052)

Warsaw, Masovian Voivodeship 02-793, Poland

Polsko-Amerykańskie Kliniki Serca ( Site 3077)

Kędzierzyn-Koźle, Opole Voivodeship 47-200, Poland

Centrum Medyczne Medyk ( Site 3065)

Rzeszów, Podkarpackie Voivodeship 35-055, Poland

Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik ( Site 3073)

Sokółka, Podlaskie Voivodeship 16-100, Poland

Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman

Gdynia, Pomeranian Voivodeship 81-157, Poland

Cooperativa De Facultad Medica Sanacoop-Instituto Sanacoop ( Site 3151)

Bayamón, 00961, Puerto Rico

Private Practice - Dr. Yolanda Figueroa-Torres ( Site 3156)

Humacao, 00791, Puerto Rico

Research and Cardiovascular Corp. ( Site 3152)

Ponce, 00717, Puerto Rico

Caparra Internal Medicine ( Site 3155)

Rio Grande, 00745, Puerto Rico

VA Caribbean Healthcare System ( Site 3157)

San Juan, 00921-3201, Puerto Rico

Ivanovo Regional Healthcare Institution Cardiology Dispensary ( Site 3265)

Ivanovo, Ivanovo Oblast 153012, Russia

Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo ( Site 3281)

Krasnodar, Krasnodarskiy Kray 350086, Russia

City Hospital No. 4 ( Site 3269)

Sochi, Krasnodarskiy Kray 354057, Russia

First Pavlov State Medical University of Saint Petersburg-Сardiology department ( Site 3257)

Saint Petersburg, Leningradskaya Oblast' 197022, Russia

State budgetary Healthcare Institution of the city of Moscow "V. V. Vinogradov City Clinical Hospita

Moscow, Moscow 117292, Russia

Omsk Regional Clinical Health Service Number 9 ( Site 3296)

Omsk, Omsk Oblast 644018, Russia

Perm Regional Hospital for War Veterans ( Site 3272)

Perm, Permskiy Kray 614990, Russia

Rostov State Medical University ( Site 3259)

Rostov-on-Don, Rostov Oblast 344022, Russia

Rostov-on-Don City Emergency Hospital ( Site 3271)

Rostov-on-Don, Rostov Oblast 344068, Russia

Ryazan State Medical University named after Academician I.P. Pavlova ( Site 3260)

Ryazan, Ryazan Oblast 390005, Russia

First Pavlov State Medical University of Saint Petersburg ( Site 3288)

Saint Petersburg, Sankt-Peterburg 197022, Russia

Almazov National Medical Research Centre ( Site 3320)

Saint Petersburg, Sankt-Peterburg 197341, Russia

Pokrovskaya Municipal Hospital ( Site 3252)

Saint Petersburg, Sankt-Peterburg 199106, Russia

Pokrovskaya Municipal Hospital-1-st cardiology department ( Site 3251)

Saint Petersburg, Sankt-Peterburg 199106, Russia

Astarta Clinic ( Site 3276)

Saint Petersburg, Sankt-Peterburg 199226, Russia

Clinical Hospital S.R.Mirotvortseva name SSMU ( Site 3254)

Saratov, Saratov Oblast 410054, Russia

Interregional Clinical Diagnostic Center-Department of Clinical Trials ( Site 3307)

Kazan', Tatarstan, Respublika 420101, Russia

Volgograd State Medical University ( Site 3258)

Volgograd, Volgograd Oblast 400131, Russia

Institute for Medical Research ( Site 3316)

Saint Petersburg, 196084, Russia

National Heart Centre Singapore ( Site 3351)

Singapore, Central Singapore 169609, Singapore

Tan Tock Seng Hospital ( Site 3353)

Singapore, Central Singapore 308433, Singapore

Changi General Hospital ( Site 3356)

Singapore, South East 529889, Singapore

National University Heart Centre, Singapore-Department of Cardiology ( Site 3355)

Singapore, South West 119074, Singapore

Universitas Private Hospital-Cardiology Research ( Site 3453)

Bloemfontein, Free State 9321, South Africa

Lenasia Clinical Trial Centre - Johannesburg ( Site 3470)

Johannesburg, Gauteng 1821, South Africa

Netcare Sunninghill Hospital ( Site 3457)

Johannesburg, Gauteng 2196, South Africa

Midrand Medical Centre ( Site 3466)

Midrand, Gauteng 1685, South Africa

University of Pretoria - Faculty of Health Sciences-CRU ( Site 3462)

Pretoria, Gauteng 0001, South Africa

Clinical Trial Systems ( Site 3452)

Pretoria, Gauteng 0186, South Africa

Jongaie Research ( Site 3469)

Pretoria West, Gauteng 0183, South Africa

Chris Hani Baragwanath Academic Hospital ( Site 3455)

Soweto, Gauteng 2013, South Africa

Enhancing Care Foundation ( Site 3456)

Durban, KwaZulu-Natal 4001, South Africa

Tiervlei Trial Centre ( Site 3461)

Bellville, Cape Town, Western Cape 7530, South Africa

TREAD Research ( Site 3451)

Cape Town, Western Cape 7500, South Africa

Professor Ntsekhe Cardiology Clinic ( Site 3454)

Cape Town, Western Cape 7925, South Africa

Excellentis Clinical Trial Consultants ( Site 3464)

George, Western Cape 6529, South Africa

Paarl Research Centre ( Site 3468)

Paarl, Western Cape 7646, South Africa

Gachon University Gil Medical Center ( Site 3559)

Namdong-gu, Incheon 21565, South Korea

Yonsei University-Wonju Severance Christian Hospital ( Site 3555)

Wŏnju, Kang-won-do 26426, South Korea

Chonnam National University Hospital ( Site 3558)

Gwangju, Kwangju-Kwangyokshi 61469, South Korea

Hallym University Sacred Heart Hospital-Cardiovascular center ( Site 3556)

Anyang-si, Kyonggi-do 14068, South Korea

Chungbuk National University Hospital-Internal medicine ( Site 3551)

Cheongju-si, North Chungcheong 28644, South Korea

Pusan National University Hospital-Internal Medicine ( Site 3553)

Busan, Pusan-Kwangyokshi 49241, South Korea

Chungnam national university hospital ( Site 3554)

Junggu, Taejon-Kwangyokshi 35015, South Korea

Seoul National University Hospital ( Site 3557)

Seoul, 03080, South Korea

Severance Hospital, Yonsei University Health System ( Site 3552)

Seoul, 03722, South Korea

Hospital Germans Trias i Pujol ( Site 3664)

Badalona, Barcelona 08916, Spain

Hospital Quiron Barcelona ( Site 3655)

Barcelona, Catalonia 08023, Spain

Hospital Universitari de Bellvitge-Unitat Multidisciplinar d'Insuficiència Cardíaca Comunitària (UM

L'Hospitalet de Llobregat, Catalonia 08907, Spain

CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 3666)

A Coruña, La Coruna 15006, Spain

CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 3651)

Santiago de Compostela, La Coruna 15706, Spain

Hospital Universitario Ramón y Cajal ( Site 3662)

Madrid, Madrid, Comunidad de 28034, Spain

HOSPITAL CLINICO DE VALENCIA ( Site 3656)

Valencia, Valenciana, Comunitat 46010, Spain

Parc de Salut Mar - Hospital del Mar ( Site 3663)

Barcelona, 08003, Spain

Hospital Universitari Vall d'Hebron ( Site 3659)

Barcelona, 08035, Spain

Hospital Clinico San Carlos-Cardiology ( Site 3661)

Madrid, 28040, Spain

Hospital Universitario La Paz ( Site 3665)

Madrid, 28046, Spain

Hospital Universitario Virgen de Valme ( Site 3654)

Seville, 41014, Spain

Falu Lasarett-Dep of Cardiology ( Site 3756)

Falun, Dalarna County 791 31, Sweden

Clemenstorgets Hjartmottagning ( Site 3755)

Lund, Skåne County 22221, Sweden

Karolinska Universitetssjukhuset Solna-Heart and Vascular theme ( Site 3759)

Solna, Stockholm County 171 64, Sweden

Aleris Specialistvård Sabbatsberg ( Site 3762)

Stockholm, Stockholm County 113 61, Sweden

Akardo Med Site ( Site 3763)

Stockholm, Stockholm County 117 27, Sweden

Skellefteå Lasarett-Research unit, floor 5 ( Site 3760)

Skellefteå, Västerbotten County 931 86, Sweden

Västmanlands Sjukhus Västerås ( Site 3757)

Västerås, Västmanland County 72189, Sweden

Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 3753)

Gothenburg, Västra Götaland County 413 45, Sweden

Universitetssjukhuset Örebro-Heart-Lung-Physiology Clinic ( Site 3754)

Örebro, Örebro County 701 85, Sweden

Changhua Christian Hospital ( Site 3857)

Changhua County, Changhua 50006, Taiwan

Mackay Memorial Hospital-Hsinchu ( Site 3852)

Hsinchu, Hsinchu 300, Taiwan

Kaohsiung Medical University Hospital ( Site 3856)

Kaohsiung City, 807, Taiwan

Taichung Veterans General Hospital ( Site 3855)

Taichung, 407, Taiwan

Taipei Veterans General Hospital-General Clinical Research Center ( Site 3851)

Taipei, 11217, Taiwan

Chang Gung Medical Foundation-Linkou Branch ( Site 3854)

Taoyuan, 333, Taiwan

Ege University Medicine of Faculty-Cardilogy Department ( Site 4054)

Bornova, İzmir 35100, Turkey (Türkiye)

Afyon Kocatepe Üniversitesi Tıp Fakültesi-Cardiology Department ( Site 4058)

Afyonkarahisar, 03200, Turkey (Türkiye)

Hacettepe Universitesi ( Site 4061)

Ankara, 06230, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi-cardiology ( Site 4053)

Ankara, 06800, Turkey (Türkiye)

Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 4064)

Antalya, 07100, Turkey (Türkiye)

Eskisehir Osmangazi University-Cardiology ( Site 4052)

Eskişehir, 26480, Turkey (Türkiye)

Istanbul University Cerrahpasa Medical School Internal Diseases Institute-CARDIOLOGY INSTITUTE ( Sit

Istanbul, 34098, Turkey (Türkiye)

Başkent Üniversitesi Istanbul Hastanesi ( Site 4057)

Istanbul, 34662, Turkey (Türkiye)

Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 4063)

Istanbul, 34668, Turkey (Türkiye)

Dokuz Eylül Üniversitesi-CARDIOLOGY ( Site 4055)

Izmir, 35340, Turkey (Türkiye)

Medical Park zmir Hastanesi-cardiology ( Site 4059)

Izmir, 35510, Turkey (Türkiye)

Kocaeli Üniversitesi-Cardiology ( Site 4060)

Kocaeli, 41380, Turkey (Türkiye)

Mersin University ( Site 4056)

Mersin, 33343, Turkey (Türkiye)

Communal non-profit enterprise "Cherkasy Regional Hospital of Сherkasy Regional Council" ( Site 4292

Cherkasy, Cherkasy Oblast 18000, Ukraine

Cherkasy Regional Hospital-Cardiorheumatology ( Site 4283)

Cherkasy, Cherkasy Oblast 18009, Ukraine

Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 4284)

Ivano-Frankivsk, Ivano-Frankivsk Oblast 76000, Ukraine

Municipal Non-commercial Enterprise "Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Fr

Ivano-Frankivsk, Ivano-Frankivsk Oblast 76018, Ukraine

Central clinical hospital - Ukrzalisnytsia-2nd Cardiology ( Site 4306)

Kharkiv, Kharkiv Oblast 61000, Ukraine

Communal non-profit enterprise "City Clinical Hospital # 27" of Kharkiv City Council ( Site 4262)

Kharkiv, Kharkiv Oblast 61000, Ukraine

L.T. Mala National Institute of Therapy of NAMS of Ukraine-Clinical Pharmacology and Pharmacogeneti

Kharkiv, Kharkiv Oblast 61039, Ukraine

Municipal Non-Profit Enterprise -City clinical hospital No8 of Kharkiv city council ( Site 4278)

Kharkiv, Kharkiv Oblast 61176, Ukraine

Khmelnytskyi Regional Cardiovascular Center-department of invasive cardiology and interventional ra

Khmelnytskyi, Khmelnytskyi Oblast 29001, Ukraine

Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain

Kiev, Kyiv Oblast 03049, Ukraine

Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 4257)

Kiev, Kyiv Oblast 04050, Ukraine

Medbud Clinic ( Site 4265)

Kyiv, Kyivska Oblast 03037, Ukraine

State Institution National Scientific Center M.D. Strazhesko-Essential Hypertension ( Site 4259)

Kyiv, Kyivska Oblast 03680, Ukraine

Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 42

Odesa, Odesa Oblast 65025, Ukraine

Ukrayins'kyy Derzhavnyy Naukovo-Doslidnyy Instytut Rebilitatsiyi Invalidiv ( Site 4274)

Vinnytsia, Vinnytsia Oblast 21029, Ukraine

Lutsk City Clinical Hospital-Center for Cardiovascular Disease ( Site 4255)

Lutsk, Volyn Oblast 43024, Ukraine

Zakarpattya Regional Clinical Cardiology Dispensary-Dept. of Hospital Therapy, Uzhhorod National Un

Uzhhorod, Zakarpattia Oblast 88000, Ukraine

Communal Non-profit Enterprise "City Hospital #6" Zaporizhzhia City Counci-Therapy department ( Site

Zaporizhia, Zaporizhzhia Oblast 69035, Ukraine

Communal nonprofit enterprise "City Hospital #9" of Zaporizhzhia City Council ( Site 4251)

Zaporizhia, Zaporizhzhia Oblast 69065, Ukraine

Communal Enterprise "Hospital #1" of Zhytomyr City Council-Advisory and Treatment department of Sci

Zhytomyr, Zhytomyr Oblast 10002, Ukraine

Consultative - Diagnostic Centre of Pechersky District-Therapeutic department ( Site 4307)

Kyiv, 01103, Ukraine

MNE " Kyiv City Clinical Emergency Hospital" of Kyiv Regional Council (KCSA) ( Site 4256)

Kyiv, 02166, Ukraine

State Institution National Scientific Center M.D. Strazhesko-Department of clinical arrhythmology a

Kyiv, 03151, Ukraine

State Institution National Scientific Center M.D. Strazhesko-Resuscitation and Intensive care ( Site

Kyiv, 03680, Ukraine

Cumberland Infirmary ( Site 4174)

Carlisle, Cumbria CA2 7HY, United Kingdom

West Cumberland Hospital ( Site 4176)

Whitehaven, Cumbria CA28 8JG, United Kingdom

Chesterfield Royal Hospital ( Site 4159)

Calow Chesterfield, Derbyshire S44 5BL, United Kingdom

Ninewells Hospital and Medical School-Cardiology ( Site 4164)

Dundee, Dundee City DD1 9SY, United Kingdom

Carmel Medical Practice ( Site 4152)

Darlington, England DL3 7RD, United Kingdom

Russells Hall Hospital ( Site 4153)

Dudley, England DY1 2HQ, United Kingdom

King's College Hospital-Cardiac Research Department ( Site 4154)

London, England SE5 9RS, United Kingdom

St. George's Hospital-Cardiology Clinical Academic Group ( Site 4156)

London, England SW17 0QT, United Kingdom

Prince Charles Hospital ( Site 4171)

Merthyr Tydfil, Great Britain CF47 9DT, United Kingdom

Layton Medical Centre ( Site 4184)

Blackpool, Lancashire FY3 7EN, United Kingdom

Ulster Hospital ( Site 4185)

Belfast, Lisburn And Castlereagh BT16 1RH, United Kingdom

William Harvey Heart Centre ( Site 4169)

London, London, City of EC1M 5PZ, United Kingdom

Craigavon Area Hospital ( Site 4162)

Belfast, Northern Ireland BT63 5QQ, United Kingdom

Princess of Wales Hospital ( Site 4178)

Bridgend, Wales CF31 1RQ, United Kingdom

Walsall Manor Hospital ( Site 4179)

West Midlands, Walsall WS2 9PS, United Kingdom

Worcestershire Royal Hospital-Cardiology Research Department ( Site 4181)

Worcester, Worcestershire WR5 1DD, United Kingdom

Blackpool Victoria Hospital ( Site 4161)

Blackpool, FY3 8NR, United Kingdom

University Hospital Coventry & Warwickshire-Research & Development ( Site 4170)

Coventry, CV2 2DX, United Kingdom

The Adam Practice ( Site 4180)

Poole, BH16 5PW, United Kingdom

University Hospital of North Tees ( Site 4172)

Stockton-on-Tees, TS19 8PE, United Kingdom