For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit: www.BMSStudyConnect.com
Inclusion Criteria:
- Male or female between 18 to 75 years of age, inclusive, and body mass index (weight kg/m2) between 18 and 35 kg/m2 (inclusive), and body weight 50 kg and 120 kg (inclusive)
- Judged to be generally in good health based on medical history, physical examination, ECGs, vital signs and laboratory tests
- Signed an informed consent document indicating they understand the purpose of and procedures required for the experiment and are willing to participate in the experiment
- Willing/able to adhere to the visit schedule
- For treatment arms groups with stable CAD participants (not for healthy volunteers without CAD) one or more of: Prior angiographically proven CAD (>50% stenosis of proximal coronary artery), prior coronary revascularization (PCI or CABG), prior myocardial infarction (MI)
Exclusion Criteria:
- Participants who meet any of the following criteria will be excluded from participating in the experiment: Allergies or intolerance of aspirin, ticagrelor and BMS-986141, requirement for dual antiplatelet therapy, requirement for anticoagulant therapy
- Acute Coronary syndrome or coronary revascularization within 3 months
- Coagulation disorders (including any abnormal bleeding or blood dyscrasias), anemia, renal or hepatic insufficiency or any others illness that the investigator considers should exclude the participants/patients of that could interfere with the interpretation to the results
- Acute illness, including a common cold, within 7 days prior to visit or other significant acute or chronic medical illness
- Major or traumatic surgery within 12 weeks of screening
- History of, a reason to believe that, a blood donor subject has a history of drug or alcohol abuse within the past 5 years or has not abstained from alcohol for at least 24 hours prior to visit
- Positive serum or urine pregnancy test
- Not anatomically suitable for or unwilling to undergo venipunctures
- Participation in a study of an investigational medicinal product within the last 4 weeks
- Any condition that, in the opinion of the investigator, would compromise the wellbeing of the blood donor subject or the experiment or prevent the blood donor subject from meeting or performing experiment requirements
Other protocol-defined inclusion/exclusion criteria apply