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Acute appendicitis is a common and potentially serious medical condition which can be difficult to diagnose, especially in pediatric patients. To help recognize patients with acute appendicitis, number of laboratory and radiological test are used. Previous research has shown that Circulating Human Leucine-rich α-2-glycoprotein (LGR1) in the blood can be elevated in pediatric patients with acute appendicitis. The aim of this research is to analyse whether LGR1 levels in saliva can be used as a less invasive diagnostic method in pediatric patients with suspected acute appendicitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with acute appendicitis | Patients with acute appendicitis, after surgery and with pathohistological specimen confirmation. |
| |
| Patients without acute appendicitis | Patients without acute appendicitis, after laboratory, clinical and/or radiological exclusion of acute admittance. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood specimen collection | Diagnostic Test | Blood specimen collection for analysis of CRP (C-reactive protein), WBC (White blood cells) and LRG1 (Circulating Human Leucine-rich α-2-glycoprotein) levels |
| Measure | Description | Time Frame |
|---|---|---|
| Level of LGR1 protein in blood | Levels of LGR1 protein in blood and saliva as measured by ELISA test | 72 hours |
| Level of LGR1 protein saliva | Levels of LGR1 protein in saliva as measured by ELISA test | 72 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Patients from 5 to 17 years of age, presenting with acute abdominal pain consistent with diagnosis of acute appendicitis, to Emergency Surgery Department at the University Hospital Split.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Goran Tintor, MD | Contact | +38521557111 | gogitintor@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Split | Recruiting | Split | Split-Dalmatia County | 21000 | Croatia |
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| ID | Term |
|---|---|
| D001064 | Appendicitis |
| ID | Term |
|---|---|
| D059413 | Intraabdominal Infections |
| D007239 | Infections |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Saliva specimen collection | Diagnostic Test | Saliva specimen collection for analysis of LRG1 (Circulating Human Leucine-rich α-2-glycoprotein) levels |
|
| D004066 |
| Digestive System Diseases |
| D002429 | Cecal Diseases |
| D007410 | Intestinal Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |