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To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blank control group | No Intervention | ||
| Exercise group | Experimental |
| |
| Hyperlipidemia group | No Intervention | ||
| Hyperlipidemia and medication group | No Intervention | ||
| Hyperlipidemia and exercise group | Experimental |
| |
| Hyperlipidemia and medication and exercise group | Experimental |
| |
| Routine treatment group | No Intervention | ||
| Routine treatment and exercise group | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise | Behavioral | Upper limb resistance training with blood flow obstruction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Endothelium dependent vasodilation | Percentage of the change | 8 weeks |
| Blood lipid analysis results | Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The inflammatory state | Content of NO, eNOS, iNOS, IFN-γ, IL-6, IL-10 in blood | 8 weeks |
| Endothelial repair function | eNOSmRNA, iNOSmRNA, EPCs in blood |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aicui Lin, PhD | Contact | +8615305179718 | linaicui@126.com | |
| JunXia Zhang, PhD | Contact | +8615850770739 | 15850770739@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Aicui Lin, PhD | Nanjing First Hospital, Nanjing Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanjing First Hospital | Recruiting | Nanjing | Jiangsu | 210006 | China |
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| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 8 weeks |