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For patients with mild head trauma, a large number of CT scans are performed. The S100B protein allows, when the dosage is below the threshold, to rule out the diagnosis of brain damage with a negative predictive value of 98%.
In patients over 65 years old it was found that the dosage of S100B came back positive more often compared to a younger population.
This study proposes to determine the positivity threshold value for S100B dosage in patients over 65 years old. In patients over 65 years suffering from mild head trauma, a head CT will systematically be performed (in accordance with the recommendations) and the S100B will be measured (taken from an additional tube on the blood test carried out in these patients). The results of the TDM will then be compared with the results of the S100B to determine the values of sensitivity, specificity, negative and positive predictive value of different thresholds.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients over 65 years old who have undergone a mild head trauma. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnostic performance of the S100B protein dosage | Diagnostic Test | Dosage of the S100B protein in patients with mild head trauma with complication risks |
|
| Measure | Description | Time Frame |
|---|---|---|
| The threshold of the S100B protein | This outcome measure is assessed on Day 1. |
| Measure | Description | Time Frame |
|---|---|---|
| - Sensitivity (Se) and Specificity (Sp) of the S100B protein in the differential diagnosis of bleeding - Positive predictive value and negative predictive value of the S100B protein in the differential diagnosis of hemorrhage |
|
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Inclusion Criteria:
Exclusion Criteria:
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Patients over 65 years old who have undergone a mild head trauma.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Etienne QUOIRIN, Dr | Contact | 03 88 12 86 52 | +333 | etienne.quoirin@chru-strasbourg.fr |
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| This outcome measure is assessed on Day 1. |