The purpose of this study is to evaluate the effect of curcuminoids and Boswellia serrata extracts combination (Flexofytol PLUS) in support to standard treatments during a 12-weeks period on hand pain on people with chronic hand joint discomfort.

Inclusion Criteria:

• Older dan 45 years old,
• With hand joint chronic discomfort,
• Regularly uses of paracetamol or NSAIDs to manage pain,
• Painful symptoms must have been present for more than 6 months,
• The patient assesses their pain on a visual pain scale and must be greater than 4 out of 10 over the last 48 hours.

Exclusion Criteria:

• Related to previous and associated treatments:

  • Corticosteroids injection in the 3 previous months, whatever the joint concerned,
  • Use of Slow-acting drugs for OA and/or dietary supplements taken within less than 6 months prior to the study (ex: chondroitin sulfate, diacerein, soy and avocado unsaponifiables, oxaceprol, granions de cuivre, glucosamine, phytotherapy or homeopathy for hand joint discomfort..),
  • Anticoagulant (coumarinic) treatment and heparin,
  • General corticotherapy in the 3 previous months,
  • Contraindication to paracetamol, curcumin, boswellia and NSAID's.

• Related to associated pathologies:

  • Patient suffering from serious associated illness (liver failure, kidney failure, non-controlled cardiovascular diseases...),
  • The patient has rheumatoid arthritis or gout,
  • The patient has a bile obstruction.

• Related to patient:

  • Pregnant or breastfeeding women.

adults above 45 years with chronic hand joint discomfort