Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 111580763245 | Other Grant/Funding Number | Minciencias |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS) | OTHER_GOV |
Not provided
Not provided
Not provided
Not provided
Healthy adult volunteers (n= 105; 18-59 years) were randomly allocated to consume daily for 8 weeks, either two whole eggs (egg group), two whole eggs added with annatto (annatto-enriched egg group), or two egg whites (control). Volunteers were asked to continue with the habitual physical activity and diet, except for the consumption of additional eggs, egg whites or annatto.
It is hypothesized that participants consuming eggs would have a less atherogenic lipid profile, feel more satisfied and increase antioxidant levels in blood, compared to the control group. Participants in the annatto-enriched egg group would have greater antioxidant capacity than the egg group and compared to control.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Whole egg | Experimental | Two whole eggs (50g each) to be eaten daily during 8 weeks |
|
| Annatto-enriched egg | Experimental | Two whole eggs (50g each) enriched with annatto (Bixa orellana L.) to be eaten daily during 8 weeks. Dose of annatto: 1,2 mg bixin/kg of body weight. |
|
| Egg whites - Control | Placebo Comparator | Two egg whites to be eaten daily during 8 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole egg | Dietary Supplement | Daily consumption of two whole eggs during 8 weeks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Total cholesterol | Fasting blood total cholesterol in mg/dL | Change from Baseline Total cholesterol at 8 weeks |
| Low-density lipoprotein (LDL) cholesterol | Fasting blood LDL cholesterol in mg/dL | Change from Baseline LDL cholesterol at 8 weeks |
| Very low-density lipoprotein (VLDL) cholesterol | Fasting blood VLDL cholesterol in mg/dL | Change from Baseline VLDL cholesterol at 8 weeks |
| Triglycerides | Fasting blood triglycerides in mg/dL | Change from Baseline Triglycerides at 8 weeks |
| High-density lipoprotein (HLDL) cholesterol | Fasting blood HLDL cholesterol in mg/dL | Change from Baseline HDL cholesterol at 8 weeks |
| Glucose | Fasting blood glucose in mg/dL | Change from Baseline Glucose at 8 weeks |
| Systolic Blood Pressure | Systolic blood pressure in mmHg will be used to present the results of this variable, as follow: e.g. 130 mmHg | Change from Baseline Systolic Blood Pressure at 8 weeks |
| Diastolic Blood Pressure | Diastolic blood pressure in mmHg will be used to present the results of this variable, as follow: e.g. 85 mmHg |
| Measure | Description | Time Frame |
|---|---|---|
| Ancestry Informative Marker | Percentage of genetic ethnicity of European, Amerindian and African for each participant | Baseline |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Jacqueline Barona-Acevedo, PhD | Universidad de Antioquia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sede de Investigación Universitaria - Universidad de Antioquia | Medellín | Antioquia | Colombia |
Not provided
Not provided
Not provided
Not provided
Not provided
| Annatto-enriched egg |
| Dietary Supplement |
Daily consumption of two whole eggs enriched with annatto during 8 weeks |
|
| Egg whites - Control | Dietary Supplement | Daily consumption of two eggs whites during 8 weeks |
|
| Change from Baseline Diastolic Blood Pressure at 8 weeks |
| Body Mass Index (BMI) in kg/m^2: weight in kilograms, height in meters | weight and height will be combined to report BMI in kg/m^2 | Change from Baseline BMI at 8 weeks |
| Waist circumference | Waist circumference in centimeters measured at the superior border of the iliac crest | Change from Baseline Waist circumference at 8 weeks |
| Blood lutein levels | Fasting blood lutein levels in micrograms per mL | Change from Baseline Blood lutein levels at 8 weeks |
| Dietary lutein+zeaxanthin levels | Dietary lutein+zeaxanthin levels in micrograms | Change from Baseline Dietary lutein+zeaxanthin levels at 8 weeks |
| Blood bixin levels | Fasting blood bixin levels in % | Change from Baseline Blood bixin levels at 8 weeks |
| Triglyceride-Rich lipoprotein (TRLP) size | Fasting blood subclasses (Large, medium, small) of TRLP in nmol/L measured by Nuclear Magnetic Resonance | Change from Baseline TRLP size at 8 weeks |
| Low-density lipoprotein (LDL) size | Fasting blood subclasses (Large, medium, small) of LDL in nmol/L measured by Nuclear Magnetic Resonance | Change from Baseline LDL size at 8 weeks |
| High-density lipoprotein (HDL) size | Fasting blood subclasses (Large, medium, small) of HDL in μmol/L measured by Nuclear Magnetic Resonance | Change from Baseline HDL size at 8 weeks |
| Apolipoprotein B (ApoB) | Fasting blood ApoB in mg/L measured by Nuclear Magnetic Resonance | Change from Baseline ApoB at 8 weeks |
| Apolipoprotein A1 (ApoA1) | Fasting blood ApoA1 in mg/L measured by Nuclear Magnetic Resonance | Change from Baseline ApoA1 at 8 weeks |
| Ghrelin | Ghrelin in pg/mL | Change from Baseline Ghrelin at 8 weeks |
| Visual Analog Scale (VAS) to Measure Perceived Hunger and Satiety | "Visual Analog Scale to measure perceived hunger and satiety" to complete in the morning, fasting, 5 days before entering the study and the last 5 days to end the study (8th week). The VAS consist of 8 questions followed each by a line of 10cm in which the person marks a position corresponding to his/her feelings about hunger and satiety. A higher score (10) means the person feels with more hunger or satisfied. | Change from Baseline VAS of Hunger and Satiety at 8 weeks |