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| ID | Type | Description | Link |
|---|---|---|---|
| J2A-JE-GZGB | Other Identifier | Eli Lilly and Company |
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The main purpose of this study is to learn about the side effects of LY3502970 when given to Japanese participants with type 2 diabetes mellitus (T2DM). Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. For each participant, the study will last up to 24 weeks, inclusive of screening and will include 10 visits to the study center.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LY3502970 (Part A) | Experimental | Single doses of LY3502970 administered orally. |
|
| LY3502970 (Part B) | Experimental | Multiple doses of LY3502970 administered orally. |
|
| Placebo (Part A) | Placebo Comparator | Placebo administered orally. |
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| Placebo (Part B) | Placebo Comparator | Placebo administered orally. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LY3502970 | Drug | Administered orally |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration | A summary of TEAEs, SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module | Baseline through Week 15 |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3502970 | PK: Cmax of LY3502970 | Predose on Day 1 through up to Day 88 |
| PK: Area Under the Concentration Versus Time Curve (AUC) of LY3502970 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) | Eli Lilly and Company | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Corporation Heishinkai OPHAC Hospital | Osaka | Osaka | 532-0003 | Japan | ||
| P-One Clinic |
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| Label | URL |
|---|---|
| A Study of LY3502970 in Japanese Participants With Type 2 Diabetes Mellitus | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 30, 2026 | |
| Reset | May 28, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 30, 2026 | May 28, 2026 | |||
| Jun 18, 2026 |
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C000729680 | orforglipron |
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| Placebo |
| Drug |
Administered orally |
|
PK: AUC of LY3502970
| Predose on Day 1 through up to Day 88 |
| Change from Baseline in Fasting Glucose | Change from Baseline in Fasting Glucose | Baseline through Day 85 |
| Change from Baseline in Glycated Hemoglobin (HbA1c) | Change from Baseline in HbA1c | Baseline through Day 85 |
| Change from Baseline in Body Weight | Change from Baseline in Body Weight | Baseline through Day 88 |
| HachiĆji |
| Tokyo |
| 192-0071 |
| Japan |
| Clinical Research Hospital Tokyo | Shinjuku-ku | Tokyo | 162-0053 | Japan |
| Medical Corporation Houeikai Sekino Clinical Pharmacology Clinic | Toshima City | Tokyo | 171-0014 | Japan |
| Yokohama Minoru Clinic | Yokohama | 232-0064 | Japan |
| D004700 | Endocrine System Diseases |