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For hypotension after spinal anesthesia, metaraminol has different 90% effective doses in the supine position and the left-tilt position. We plan to conduct a non-inferiority trial to compare the effects of the two on the fetus and the mother.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| left-tilt group | Placebo Comparator | After spinal anesthesia, the patient was placed in a 15° left position until the fetus was delivered, and metaraminol was given at an initial rate of 2.00μg/kg/min throughout the process. |
|
| supine group | Experimental | After spinal anesthesia, the patient was placed in a supine position until the fetus was delivered, and metaraminol was given at an initial rate of 2.7μg/kg/min throughout the process. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metaraminol 2.7μg/kg/min | Drug | After spinal anesthesia, the patient was placed in a supine position until the fetus was delivered, and metaraminol was given at an initial rate of 2.7μg/kg/min throughout the process. |
| Measure | Description | Time Frame |
|---|---|---|
| Umbilical artery blood pH | pH value of fetal umbilical artery blood | 30 seconds after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| hypotension | Number of Participants with systolic blood pressure reduction >20% baseline value or systolic blood pressure <90 mm Hg before delivery | Intraoperative |
| bradycardia | Number of Participants with heart rate was ≤50 bpm before delivery Number of Participants with heart rate was ≤50 bpm before delivery Number of Participants with heart rate was ≤50 bpm before delivery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Feng Yi | Peking University People's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University People's Hospital | Beijing | Beijing Municipality | 100044 | China |
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| ID | Term |
|---|---|
| D008680 | Metaraminol |
| ID | Term |
|---|---|
| D010665 | Phenylpropanolamine |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
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| Metaraminol 2μg/kg/min | Drug | After spinal anesthesia, the patient was placed in left-tilt position until the fetus was delivered, and metaraminol was given at an initial rate of 2μg/kg/min throughout the process. |
|
| Intraoperative |
| The incidence of nausea in pregnant women | Anesthesiologist observes combined patient dictation. | Intraoperative |
| Umbilical artery blood base excess | base excess of fetal umbilical artery blood | 30sec after delivery |
| The incidence of vomiting in pregnant women | Anesthesiologist observes combined patient dictation | Intraoperative |
| D009930 |
| Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |