ECMO is increasingly used in critically ill patients with severe circulatory and/or respiratory failure. Because of the catheterization of the femoral artery and femoral vein, usage of sedatives, and occasionally with neuromuscular blockers, ECMO patients are generally considered unsuitable for early activity. However, some recent retrospective studies and a small number of single-center, small-scale prospective studies have shown that early activity of ECMO patients is feasible, and early active activity is associated with recovery of independent function and reduction of delirium incidence.

Inclusion Criteria:

• ECMO time ≥1 day
• Aged older than16 years old and less than 70 years old

Exclusion Criteria:

• coma deep
• sedation muscle relaxation (RAAS-3-5)
• Active bleeding deep vein thrombosis
• High dose of vasoactive drugs
• unstable vital signs
• Acute stage of myocardial infarction (within 2d)
• Malignant arrhythmia
• pregnancy