The Expression Profile of New Complement Components in Childhood Lupus Nephritis

The Expression Profile of New Complement Components in Childhood Lupus Nephritis

The aim of this study was to evaluate whether C4d is a better biomarker and examine whether C4d plasma levels correlate with treatment response and C4d kidney deposition in systemic lupus erythematosus (SLE) with lupus nephritis (LN).

Evaluation of C4d in lupus nephritis in children C4d level difference in children with systemic lupus with and without renal affection C4d level in lupus nephritis at activity and after remission Detection of C4d deposition in renal tissue relation to disease activity

Inclusion Criteria:

• This will include children and adolescents who fulfill the 2012 Systemic Lupus International Collaborating Clinics (SLICC)(10) classification criteria of SLE.

  • Inclusion Criteria:

    • Age younger than 18 years.
    • Active SLE with and without renal affection
    • Patients with biopsy proven LN according to ISN/RPS classification criteria of Lupus nephritis.

Exclusion Criteria:

• -Patients in remission.