Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases. One of them is applying "remote ischemic preconditioning." This randomized controlled trial is planned to evaluate the effectiveness of remote ischemic preconditioning in preventing tourniquet-induced ischemia-reperfusion injury in total knee arthroscopy with dynamic thiol-disulfide homeostasis.

Inclusion Criteria:

• ASA I-III patients who will undergo total knee arthroplasty surgery under elective conditions

Exclusion Criteria:

• emergency operation,
• Underlying neurological disorder,
• Underlying peripheral vascular disease,
• other types of concurrent surgery.