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A faster emergence from general anesthesia has a double medico-economic impact by reducing the risks of complications and optimizing the performance of surgical units. No drug has been retained for its ability to actively accelerate anesthetic emergence by antagonizing hypnotics. Thus, the aim of this study was to examine the effect of caffeine on the time to emerge from sevoflurane anesthesia for laparoscopic cholecystectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GC group | Experimental | received 300 mg of caffeine citrate infusion |
|
| GS group | Placebo Comparator | Equivalent saline infusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 300 mg of caffeine citrate infusion | Drug | At the end of the surgery, the study drug was given intravenously over ten minutes than the sevoflurane infusion was stopped corresponding to the start of the recovery period |
| Measure | Description | Time Frame |
|---|---|---|
| anesthetic recovery time | time to return to spontaneous breathing, eye opening on verbal command and time for extubation | Postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| plasma caffeine levels at H1 and H24 | Hour 1 and Hour 24 | |
| postoperative rehabilitation | incidence of headache, nausea and vomiting, tiredness score, time to the first flatus and satisfaction of patients |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mohamed Aziz DAGHMOURI, M.D | Contact | 0021629442474 | aziz.daghmouri@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Habib Thameur Hospital | Recruiting | Tunis | Tunisia |
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| Placebo | Drug | At the end of the surgery, the placebo was given intravenously over ten minutes than the sevoflurane infusion was stopped corresponding to the start of the recovery period |
|
| 24 hours postoperatively |
| postoperative pain (Visual Analog Scale score 0 "no pain" to 10 "severe pain") and consumption of morphine | 24 hours postoperatively |