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| Name | Class |
|---|---|
| Biosense Webster, Inc. | INDUSTRY |
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The primary objective of this study is twofold, first we aim to identify rotors in atrial fibrillation (AF) and analyze their relationship with the left atrium-left atrial appendage (LA-LAA) connections. Secondly, we will analyze the areas harboring rotors in SR to define the characteristics that describe the presence of rotors.
The primary objective of this study is the identification of LA and LAA areas driving atrial fibrillation to study their relationship with LAA-LA connections and sinus rhythm (SR) analysis using the CartoFinder and COHERENT algorithms that CARTO V7 offers.
The CartoFinder tool will be able to determine the activation patterns of reentrant drivers (rotors) in the LA and LAA in AF. The characterization of areas harboring rotors could be performed with the COHERENT tool provided by CARTO V7 to determine the activation patterns during reentrant rhythms, and after sinus rhythm restoration it could be used to assess the conduction patterns at LA-LAA connections and driver sites identified with CartoFinder.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pulmonary vein electrical isolation | Procedure | Electrical isolation of the pulmonary veins from the left atrium with cryoablation therapy. |
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| Measure | Description | Time Frame |
|---|---|---|
| CartoFinder and COHERENT tools utility assessment | To evaluate the utility of CartoFinder and COHERENT tools in the identification of the mechanisms that maintain atrial fibrillation. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Atrial fibrillation driver location analysis | Reentrant driver location relationship with lines of block, wavefront curvature, and slow conduction areas during SR pacing with success AF termination. | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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The study will include 50 patients. No statistical considerations were made to determine the sample size of this study.
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| Name | Affiliation | Role |
|---|---|---|
| Ángel Arenal, MD, PhD | Hospital General Universitario Gregorio Marañón | Principal Investigator |
| Gonzalo R Ríos-Muñoz, MSc, PhD | Hospital General Universitario Gregorio Marañón | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital General Universitario Gregorio Marañón | Madrid | 28007 | Spain |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| Atrial substrate mapping | Device | Electro-anatomical maps will be performed with CARTO navigation system with multi-electrode catheters. |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |