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To assess TCI999 on hair and body health care
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo sachet | Placebo Comparator |
| |
| TCI999 probiotic sachet | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TCI999 probiotic sachet | Dietary Supplement | Testing product |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change of hair loss amount | Collected and measured the weight of loss hair | Change from Baseline hair loss amount at 12 weeks |
| The change of hair density | Take a picture and observe the hair density | Change from Baseline hair density at 12 weeks |
| The change of hair follicle strength | Pull up the hair of the frontal bone, temporal bone and occipital bone (approximately 60 hairs/area) to assess the number of hair loss in each area | Change from Baseline hair follicle strength at 12 weeks |
| The change of intestinal microbiota | To evaluate the intestinal microbiota of fecal samples | Change from Baseline intestinal microbiota at 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The change of scalp gloss | Chroma Meter MM500 was utilized to measure scalp gloss | Change from Baseline scalp gloss at 12 weeks |
| The change of scalp redness | Chroma Meter MM500 was utilized to measure scalp redness |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chia-Hua Liang | Chia Nan University of Pharmacy ＆ Science | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chia Nan University of Pharmacy ＆ Science | Tainan | 71710 | Taiwan |
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| ID | Term |
|---|---|
| D000505 | Alopecia |
| ID | Term |
|---|---|
| D007039 | Hypotrichosis |
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| Placebo sachet | Dietary Supplement | Blank |
|
| Change from Baseline scalp redness at 12 weeks |
| The change of scalp health | Soft Plus was utilized to measure hair diameter | Change from Baseline scalp health at 12 weeks |
| The change of hair diameter | Mitutoyo C/N293-100 was utilized to measure hair diameter | Change from Baseline hair diameter at 12 weeks |
| The change of dihydrotestosterone of blood | Venous blood was sampled to measure dihydrotestosterone | Change from Baseline hair diameter at 12 weeks |
| The change of testosterone of blood | Venous blood was sampled to measure testosterone | Change from Baseline testosterone at 12 weeks |
| The change of SRD5A1 gene expression of blood | Venous blood was sampled to measure SRD5A1 gene expression | Change from Baseline SRD5A1 gene expression at 12 weeks |
| The change of AR gene expression of blood | Venous blood was sampled to measure AR gene expression | Change from Baseline AR gene expression at 12 weeks |
| The change of TGF-β gene expression of blood | Venous blood was sampled to measure TGF-β gene expression | Change from Baseline TGF-β gene expression at 12 weeks |
| The change of IGF-1 gene expression of blood | Venous blood was sampled to measure IGF-1 gene expression | Change from Baseline IGF-1 gene expression at 12 weeks |
| D020763 |
| Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |