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case control study to compare level of interleukin 38 in patients with psoriasis and patients with metabolic syndrome with healthy control subjects
this case control study will measure plasma level of interleukin 38 in 4 groups of 24 subject, group one will have psoriatic patients, group 2 will have psoriatic patients with metabolic syndrome, group three will have patients with metabolic syndrome only, and group 4 will have healthy control subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 (Psoriasis only) | contains 24 psoriatic patients, Psoriasis Area Severity Index will be measured, also waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile and finally: plasma level of interleukin 38 |
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| Group 2 (Psoriasis and metabolic syndrome) | contains 24 psoriatic patients with metabolic syndrome. Psoriasis Area Severity Index will be measured metabolic syndrome is diagnosed after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38 |
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| Group 3 (Metabolic syndrome only) | contains 24 patients with metabolic syndrome only. full dermatological examination to exclude psoriasis and other inflammatory skin disorders metabolic syndrome is diagnosed after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38 |
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| Group 4 (Healthy Controls) | contains 24 healthy control subjects full dermatological examination to exclude psoriasis and other inflammatory skin disorders metabolic syndrome is excluded after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| measure plasma level of interleukin 38 by ELISA kit | Diagnostic Test | draw 5 ml of venous blood into EDTA tubes and centrifuged then plasma is separated for test |
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| Measure | Description | Time Frame |
|---|---|---|
| measure plasma level of interleukin 38 in all groups | level of interleukin 38 will be measured and compared in all groups to asses the relationship between this interleukin and metabolic syndrome in psoriatic patients | through study completion an average of 18 months |
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Inclusion Criteria:
Exclusion Criteria:
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people attending the Dermatology Outpatient Clinics of Sohag University Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yomna A Abdellatif, MBBCH | Contact | 01119200320 | +2 | yomna.a.abdellatif@gmail.com |
| wafaa m abdel-magid, asst prof | Contact | 0 100 8813349 | +2 |
| Name | Affiliation | Role |
|---|---|---|
| yomna a abdellatif, MBBCH | Principal Investigator |
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| ID | Term |
|---|---|
| D011565 | Psoriasis |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D007333 | Insulin Resistance |
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| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |