Air Pollution and Health of COPD Patients | NCT05076630

Studies
Air Pollution and Health of COPD Patients

NCT05076630

Sponsor

Peking University

Status

Completed

Last Update Posted

Jun 3, 2025Actual

Enrollment

110Actual

Phase

Not provided

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Air pollutants

Countries

China

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

May 2025

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Oct 12, 2021Actual

Primary Completion Date

Jun 30, 2024Actual

Completion Date

Dec 31, 2024Actual

First Submitted Date

Sep 16, 2021

First Submission Date that Met QC Criteria

Oct 1, 2021

First Posted Date

Oct 13, 2021Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

May 28, 2025

Last Update Posted Date

Jun 3, 2025Actual

Sponsor/Collaborators Module

Responsible Party, by Official Title

Furong Deng, Deputy Director of Department of Occupational and Environmental Health Sciences, Peking UniversityPrincipal Investigator

Lead Sponsor

Peking UniversityOTHER

Collaborators

Not provided

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

FDAAA801 Violation

Not provided

Description Module

Brief Summary

This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.

Detailed Description

This panel study was conducted in a group of stable patients with COPD in Beijing, China. The health measurements including lung function, blood pressure and airway inflammation were conducted, and morning urine, exhaled breath condensate, saliva and venous blood were collected at the time of enrollment and at 3, 6 and 9 months after enrollment. Individual exposures to fine particulate matter (PM2.5), black carbon (BC), ozone (O3) and nitrogen dioxide (NO2) were performed for 24 hours at each follow-up. And the daily concentrations of air pollutants were collected from the Beijing Air Quality Real-time Publishing Platform and meteorological data were collected from the National Meteorological Information Center. The linear mixed effects model was used to analyze the association between air pollution and cardiopulmonary health in patients with COPD.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

Retention

Enrollment

110Actual

Name	Type	Description	Arm Group Labels	Other Names
Air pollutants	Other	Particulate matter and gaseous pollutants

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Lung function	Lung function test was conducted.	Nine months

Secondary Outcomes

Measure	Description	Time Frame
COPD Assessment Test scores	COPD Assessment Test (CAT) scores were used to assess quality of life in COPD patients on a scale of 0 to 40, with higher scores associated with poorer outcomes.	Nine months
Modified British Medical Research Council (mMRC) Questionnaire score

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

doctor-diagnosed stable COPD patients
aged 40 to 80 years
lived in Beijing for over one year before being recruited
Agree to participate and sign the informed consent form.

Exclusion Criteria:

Patients with a history of acute exacerbation in the last 1 month
Patients with other respiratory diseases such as bronchiectasis and asthma.

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

40 Years

Maximum Age

80 Years

Standard Ages

AdultOlder Adult

Study Population

Stable COPD patients aged 40-80 in Beijing, China

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Name	Affiliation	Role
Furong Deng, Doctor	Peking University	Principal Investigator

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Peking University		Beijing	China	100191	China

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
41825861	Derived	Chen B, Zhang W, Chen Y, Zhao C, Zhang Z, Li S, Zhao L, Guo L, Shima M, Yoda Y, Wu S, Guo X, Deng F. Short-term effects of size-fractioned particulate matter on blood pressure in patients with COPD: the key role of inflammatory phenotypes. Thorax. 2026 Mar 13:thorax-2025-224085. doi: 10.1136/thorax-2025-224085. Online ahead of print.
40541407

ID	Term
D008173	Lung Diseases, Obstructive
D008171	Lung Diseases
D012140	Respiratory Tract Diseases
D002908	Chronic Disease

ID	Term
D004785	Environmental Pollutants
D004786	Toxic Actions
D020164	Chemical Actions and Uses