Dysregulated Urea-synthesis at Terminal Uremia

Dysregulated Urea-synthesis at Terminal Uremia

This project will examine the dysregulation of the urea cycle in patients with terminal uremia using a validated method named "Functional Hepatic Nitrogen Clearance"

Inclusion Criteria:

• Age > or equal to 18 years
• Chronic hemodialysis during 3 months
• Patients with functioning arteriovenous-fistula assigned to "Center-Hemodialysis" at "Nyresygdomme, AUH Skejby"

Exclusion Criteria:

• Active infection
• Conditions with vomiting or diarrhea
• Diabetes
• Active disease being treated with chemotherapy, radiationtherapy, biologic- or similar treatments. Disease under observation can be included.
• Liver disease
• Vessels on the upper extremities not suited for cannulation
• Prednisolone treatment during the last 8 weeks
• Pregnancy
• BMI > or equal to 30 or < or equal to 18
• Physically or mentally condition that does not allow the project to be completed
• Language-difficulties that does not allow the project to be completed