This study aim to investigate whether the prognosis of eyelid malignant tumor is better treated with Mohs surgery combind with cryotherapy than Mohs surgery only.

This study is a randomized perspective study. American Joint Committee on Cancer was applied to define the cancer stage of patients recruited. Patients with Tis to T3cN0M0 will be randomized to receive Mohs surgery or Mohs suregery conbind cryotherapy. Patients will be followed for 3 years.

Inclusion Criteria:

• Ability to provide written informed consent and comply with study assessments for the full duration of this study.
• Definite pathology signs of eyelid basal cell carcinoma, squamous cell carcinoma and sebacous carcinoma, Stage Tis to T3CN0M0 based on American Joint Committee on Cancer.
• Pathological examination showed the primary tumor was compeletely resected

Exclusion Criteria:

• Any previous treatment in the study eye
• Tumor complicated with infection
• Any other tumors of the paticipants
• Intolerate of surgery or anesthesia