The objective of this study is to assess whether Near-Infrared Fluorescence/NIR Imaging perfusion alters intraoperative management of the flap or of the participant wound bed.

Inclusion Criteria:

• Women undergoing a pelvic reconstruction procedure after radical gynecologic surgery for any indication at MSK.
• Age ≥18 years.

Exclusion Criteria:

• Women with hepatic dysfunction as evidenced by elevated transaminases (two times the upper limit of normal).
• Women with a history of cirrhosis or other chronic liver disease.
• Women with a documented severe or life threatening allergy to iodine.
• Women with an allergy to ICG or severe allergy to iodinated contrast.
• Women undergoing any free flap (non-pedicled) reconstruction.

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.