Denosumab and Screw Fixation for Osteoporotic Compression Fracture

Attending Doctor of Shenzhen People's Hospital

Evaluation of bone mineral density and function at 1 year after screw internal fixation of osteoporotic vertebral compression fractures with desuzumab: a parallel double-blind randomized controlled clinical trial

Conduct a single-center, double-blind, randomized controlled clinical trial according to clinical Trial Reporting Standards (CONSORT). Bone mineral density and function were compared 1 year after screw internal fixation of osteoporotic vertebral compression fracture (OVCF) with desomumab versus placebo in Shenzhen People's Hospital from September, 2021 to September, 2022. The study was approved by Shenzhen People's Hospital and informed consent was signed

Inclusion Criteria:• Must be age between 40 and 90 years old

• X-ray diagnosis of 1-2 vertebral compression fractures
• Dual energy X ray test bone mineral density T value less than -1
• fracture history lasted within 6 weeks
• MRI showed bone marrow edema of injured segment
• lower back pain, local spines tenderness

Exclusion Criteria:

• • Must be able to have no posterior vertebral wall fracture

  • Must be able to have no patients with intervertebral fissure
  • Must be able to have no infection
  • Must be able to have no malignancy
  • Must be able to have no neurological dysfunction
  • Must be able to have no previous use of anti-osteoporosis drugs within 6 weeks
  • Must be able to have no inability to perform magnetic resonance imaging
  • Must be able to have no prior back surgery
  • Must be able to have no other established contraindications for elective surgery