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The investigators collected clinical data and serum samples of patients with polycystic ovary syndrome in this study, used statistical software such as SPSS for data analysis, and used experimental techniques such as ELISA to detect serum samples, aiming to explore the relationship between the body anthropometry, glucose and lipid metabolism, gonadal hormones and body fat distribution in patients with polycystic ovary syndrome and to discovery new biomarkers and promote the realization of more accurate personalized medicine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PCOS |
|
| |
| NOPCOS | not meet Rotterdam standards |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| This study does not involve any interventions | Other | This study does not involve any interventions |
|
| Measure | Description | Time Frame |
|---|---|---|
| diagnostic markers of PCOS patients | Fibrinogen-like-protein 1 (FGL1), is a novel hepatokine that plays an important role in hepatic steatosis, insulin resistance and obesity. There is no maximum or minimum value for this parameter and the higher scores mean a worse outcome. | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| body mass index ,BMI | BMI=weight(kg)/height(m)^2 | baseline |
| Waist/hip Ratio,WHR | WHR=Waist Circumference(cm)/Hip Circumference(cm) | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Polycystic ovary syndrome (PCOS) is a common dis-order in women that is characterized by hyperandro-genism (that is, evidence of excess male hormone or androgen effect; clinically, such as hirsut-ism, and/or biochemically, such as hyperandrogen aemia or excess levels of androgen), ovulatory dysfunction (including menstrual dysfunction) and polycystic ovarian morphology (PCOM; an excessive number of preantral follicles in the ovaries).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Manna Zhang, Dr | Contact | （86）66301004 | mannazhang@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Shen Qu, Dr | Shang hai Tenth People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Tenth People' Hospital | Recruiting | Shanghai | Shanghai Municipality | 200072 | China |
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| ID | Term |
|---|---|
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 |
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serum samples
| Number of menstruation in the last year | physiological parameter,the total number of menstrual periods in the last year | baseline |
| Ferriman-Gallwey score | The minimum value of Ferriman-Gallwey score is 0 and the maximum value is 44. An Ferriman-Gallwey score greater than or equal to 6 is considered to be a clinical manifestation of androgen excess. | baseline |
| HOMA-IR | Homeostatic model assessment insulin resistance index | baseline |
| TT | total testosterone (nmol/L) | baseline |
| FT | Free testosterone (nmol/L) | baseline |
| SHBG | SHBG (nmol/L) | baseline |
| LH | luteinizing hormone | baseline |
| FSH | follicle-stimulating hormone | baseline |
| DHEAS | dehydroepiandrosterone | baseline |
| FBG | fasting blood-glucose; | baseline |
| PBG | postprandial blood-glucose | baseline |
| FINS | fasting serum insulin | baseline |
| PINS, | postprandial serum insulin | baseline |
| AST | aspartate aminotransferase | baseline |
| ALT | alanine aminotransferase | baseline |
| UA | Uric acid | baseline |
| CR | Creatinine | baseline |
| LDL-c | low-density lipoprotein cholesterol | baseline |
| HDL-c | high-density lipoprotein cholesterol | baseline |
| TC | Total Cholesterol (mmol/L) | baseline |
| TG | Triglyceride (mmol/L) | baseline |
| Interleukin 22，IL-22 | The factor reflects that the organism is in an inflammatory state. There is no maximum or minimum value for the factor and the higher scores mean a worse outcome. | baseline |
| Interleukin 6，IL-6 | IL-6. The factor reflects that the organism is in an inflammatory state. There is no maximum or minimum value for the factor and the higher scores mean a worse outcome. | baseline |
| Interleukin 8， IL-8 | The factor reflects that the organism is in an inflammatory state. There is no maximum or minimum value for the factor and the higher scores mean a worse outcome. | baseline |
| Tumor Necrosis Factor， TNF | The factor reflects that the organism is in an inflammatory state. There is no maximum or minimum value for the factor and the higher scores mean a worse outcome. | baseline |
| Chemerin | A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| omentin-1 | A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| leptin | A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| RBP-4 | A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| adiponectin | A adipocytokine. The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| resistin | A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| Visfatin | A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| Apelin | A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| Vaspin. | A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function. | baseline |
| Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |