Transcriptomic Study of IBD-associated Colorectal Cancer

Transcriptiomic Analysis of Inflammatory Bowel Disease-associated Colorectal Cancer. A French Retrospective Study of 26 Cases Identified at the Nancy University Hospital

Chronic inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) in historical cohorts. The pathways of oncogenesis of these CRCs, which are very different clinically from de novo CRCs, are currently unknown. The aim of our work is to identify specific molecular signatures of CRC occurring in the setting of IBD.

Inclusion Criteria:

• Person 18 years of age or older
• Person with colorectal cancer in the context of IBD
• Person who has received complete information on the organization of the research and who has signed an informed consent
• Person affiliated to a social security plan or beneficiary of such a plan.

Exclusion Criteria:

• Person referred to in articles L. 1121-5, L. 1121-7 and L1121-8 of the public health code:
• Pregnant woman, parturient or nursing mother
• Minor (not emancipated)
• Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
• Person of legal age who is unable to express his or her consent
• Person deprived of liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1 and L. 3213-1.