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| ID | Type | Description | Link |
|---|---|---|---|
| 2020-A01581-38 | Other Identifier | ANSM |
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In France, Streptococcus pneumoniae is the leading agent bacterial involved in community lung disease and meningitis. The frequency of these infections and their mortality increase significantly in those at risk such as patients with certain chronic diseases, immunocompromised or on immunosuppressive therapy. This population, despite regular monitoring, has a limited pneumococcal vaccine coverage of around 20%. By carrying out a reconciliation of treatments upon admission to hospital, the clinical pharmacist can detect those without up to date pneumococcal vaccination status. The goal of this management is to make the patient aware of the need for vaccination and organization upon return home. Thus, this limited pneumococcal vaccination coverage would benefit from intervention by regional clinical pharmacy activities. The study investigators want to study the impact of a structured medico-pharmaceutical collaboration on pneumococcal vaccination of patients with risk on discharge from hospital. The investigators hypothesize that this collaboration in patients at risk of infection with pneumococcus could significantly increase their anti-pneumococcal vaccination coverage
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard care | No Intervention | ||
| Structured medico-pharmaceutical collaboration | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Structured medico-pharmaceutical collaboration | Other | Reconciliation of drug treatments; Writing of the prescription for discharge from hospital for the pneumococcal vaccine; Pharmaceutical interview at discharge; Drafting of the discharge letter and transmission to the attending physician; Writing of the pharmaceutical discharge letter and transmission to the pharmacist; Pharmaceutical dispensing in the pharmacy; Administration of the vaccine by the attending physician or a nurse at home. |
| Measure | Description | Time Frame |
|---|---|---|
| Full vaccination coverage (2 doses) between groups | Yes/No, confirmed by the administrator | 6 months after discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Full vaccination coverage (2 doses) between groups, stratified by type of establishment (University hospital vs hospital) and by service (Medicine vs Surgery) | Yes/No, confirmed by the administrator | 6 months after discharge |
| Partial vaccination coverage (1st dose only) between groups and stratified by type of establishment (University hospital vs hospital) and by service (Medicine vs Surgery) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Florent Dubois | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CH Alès Cévennes | Alès | France | ||||
| CH de Bagnols sur Cèze |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40065836 | Result | Dubois F, Champiot-Bayard E, Cireasa B, Loubet P, Vallat J, Bonnet J, Jacob V, Puyo P, Pinzar I, Theret S, Dubois E, Peus E, Giraudon L, Roux-Marson C, Fabbro-Peray P, Leguelinel-Blache G, Kinowski JM. Prevention of pneumococcal infections: Impact of structured medico-pharmaceutical collaborative management to improve vaccination coverage of at-risk patients (OPTIVACC study): Protocol for a multicenter randomized stepped -wedge study. Contemp Clin Trials Commun. 2025 Feb 15;44:101462. doi: 10.1016/j.conctc.2025.101462. eCollection 2025 Apr. |
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Step wedge
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|
Yes/No, confirmed by the administrator |
| 6 months after discharge |
| Record of both vaccines being dispensed by the pharmacy between groups and stratified by type of establishment (University hospital vs hospital) and by service (Medicine vs Surgery) | Yes/No according to Système national d'information inter-régimes de l'Assurance maladie (SNIIRAM) database | 6 months after last follow-up visit |
| Concordance between vaccines dispensed and vaccines recorded in the SNIRRAM database between groups and stratified by type of establishment (University hospital vs hospital) and by service (Medicine vs Surgery) | Yes/No | 6 months after discharge |
| Prescription of vaccines at discharge by the doctor between groups and stratified by type of establishment (University hospital vs hospital) and by service (Medicine vs Surgery) | Yes/No | at discharge (average 5 days after hospitlization) |
| Notification of requirement for vaccine between groups and stratified by type of establishment (University hospital vs hospital) and by service (Medicine vs Surgery) | Yes/No | at discharge (average 5 days after hospitlization) |
| Transmission of letter highlighting the absence of vaccination by the pharmacy to the patient's doctor between groups and stratified by type of establishment (University hospital vs hospital) and by service (Medicine vs Surgery) | Yes/No | at discharge (average 5 days after hospitlization) |
| Bagnols-sur-Cèze |
| France |
| CH de Montauban | Montauban | France |
| CHU de Montpellier | Montpellier | France |
| CHU de Nimes | Nîmes | France |
| CH de Perpignan | Perpignan | France |
| CH Comminges Pyrénées | Saint-Gaudens | France |
| CH du Bassin de Thau | Sète | France |
| CHU de Toulouse | Toulouse | France |
| ID | Term |
|---|---|
| D011008 | Pneumococcal Infections |
| ID | Term |
|---|---|
| D013290 | Streptococcal Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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